This enzyme catalyzes the GalNAc-transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT16 is the 16th member of this enzyme family. This isozyme is identified by Raman et al. in 2012.
Keyword:
GALNACT16
, GALNTL1
, GalNAc-T16
, O-glycan
, Tn-antigen
, mucin
, tumor marker
| HO-Ser/Thr | 
|
GalNAc(alpha1-O)-Ser/Thr |
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase
| GALNT16 | |
| Designation | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16 |
| Organism | Homo sapiens |
| GeneID | 57452 |
| HGNC | |
| mRNA | NM_020692.2 |
| map | 14q24.1 |
| Protein | NP_065743.2 |
| EC# | 2.4.1.41 |
| CAZy | GT27 |
| GlyCosmos Glycogenes | GALNT16 |
| OMIM | 615132 |
| GDGDB | |
| Human Protein Atlas | ENSG00000100626 |
