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JCGG-STR001961 JCGG-STR005020
ST3GAL5, β-galactoside α-2,3-sialyltransferase 5, transfers sialic acid from CMP-sialic acid to the Galβ1→3Glc-Cer on glycolipids. ST3GAL5 is also called as GM3 synthase, SATI or SIAT9. Loss of fuction of ST3GAL5 causes a disruption of ganglioside biosynthesis, resulting in human diseases such as symptomatic epilepsy syndrome and salt-and-pepper syndrome. ST3GAL5-deficient mice demonstrated that GM3 ganglioside is involved in insulin signaling and hearing.
GM3 ganglioside


Alias SIAT9, ST3GalV, SIATGM3S    details
DesignationCMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
OrganismHomo sapiens
GeneID 8869
HGNC 10872
mRNA NM_003896       (CDS)
Protein NP_003887       (CDS)
CAZy GT29   
OMIM 604402   
This page does not indicate all of the enzymatic reaction, and expression of "ST3GAL5".