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JCGG-STR014102 JCGG-STR033514
JCGG-STR013995 JCGG-STR033515
ST8SIA2, ST8 α-N-acetylneuraminide α-2,8-sialyltransferase 2, transfers sialic acid from CMP-sialic acid to the NeuAcα2→3-R and NeuAcα2→6-R structure on glycoproteins, mainly on the neural cell adhesion molecule (NCAM), synthesizing homopolymer of α2,8-linked sialic acid called polysialic acid. ST8SIA2 is also known as STX or SIAT8B or ST8Sia-II. ST8SIA2 also synthesizes polysialic acid on the synaptic cell adhesion molecule (SynCAM 1). ST8SIA2-deficient mice exhibit morphological change of mossy fiber and loss of anxiety. Double deficient mice of ST8SIA2 and ST8SIA4 lose polysiaic acid and die in early neonatal period.


Alias STX, SIAT8B, HsT19690, MGC116854, MGC116857, ST8SIA-II    details
DesignationST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
OrganismHomo sapiens
GeneID 8128
HGNC 10870
mRNA NM_006011       (CDS)
Protein NP_006002       (CDS)
CAZy GT29   
OMIM 602546   
This page does not indicate all of the enzymatic reaction, and expression of "ST8SIA2".