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HO-Ser/Thr (Glycopeptide) GalNAc(alpha1-O)-Ser/Thr (Glycopeptide)
This enzyme catalyzes the GalNAc-transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT10 is the tenth member of this enzyme family. This exhibits strong activities toward GalNAc-glycosylated peptide. Lectin domain is functional to recognize GalNAc-glycosylated peptide substrate by X-ray crystallography by Kubota et al. (2006).
O-glycan Tn-antigen mucin tumor marker

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

Alias FLJ00205, FLJ11715, GalNAcT10, DKFZp586H0623, pp-GalNAc-T10    details
DesignationUDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 10
OrganismHomo sapiens
GeneID 55568
HGNC 19873
mRNA NM_198321       (CDS)
Protein NP_938080       (CDS)
CAZy GT27   
OMIM 608043   
This page does not indicate all of the enzymatic reaction, and expression of "GALNT10".