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JCGG-STR000334 JCGG-STR026492
JCGG-STR013782 JCGG-STR002937
JCGG-STR021541 JCGG-STR021875
This gene encodes α1,2-fucossyltransferase 2 (FUT2). In the ABO blood type, type O antigen (H antigen) is synthesized by the α1,2-FUT group, which transfers fucose to the Gal residue of Galβ1-3/4GlcNAcβ-R structure with α1-2-linkage. This enzyme is one of the three enzymes with α1,2-FUT activity known in human. This enzyme is also known as “Se enzyme”, and is mainly expressed in intestinal epithelium cells, but not expressed in myeloid cells or neuron. In the Bombay phonotype, the activity of both H enzyme (FUT1) and Se enzyme (FUT2) is lost, and the H antigen (O antigen) is not present in the erythrocyte surface nor secretory fluids. In the para-Bombay type, the H antigen is inactivated but the Se antigen has activity; therefore, the H antigen is not synthesized on the erythrocyte surface, but expressed in the intestinal tissue.
Bombay H antigen O antigen Se, Sej histoblood group antigen para-Bombay


Alias SE, Se2, sej    details
Designationalpha1,2-fucosyltransferase 2
OrganismHomo sapiens
GeneID 2524
HGNC 4013
mRNA NM_000511       (CDS)
Protein NP_000502       (CDS)
CAZy GT11   
OMIM 182100   
This page does not indicate all of the enzymatic reaction, and expression of "FUT2".