FUT3

JCGG-STR033542		JCGG-STR033543

JCGG-STR002937		JCGG-STR022315

JCGG-STR021541		JCGG-STR022093

JCGG-STR013782		JCGG-STR025761

JCGG-STR021875		JCGG-STR022421

JCGG-STR025525		JCGG-STR003256

JCGG-STR031527		JCGG-STR003144

This gene encodes α1,3-fucosyltransferase 3 (FUT3). Six α1,3-fucosyltransferases (α3FUT): FUT3, FUT4, FUT5, FUT6, FUT7, and FUT9 are known and confirmed that each has specific substrate specificity in vitro. Except FUT7, these have activity to transfer fucose to GlcNAc of the type-2 lactosamine structure (Galβ1-4GlcNAcβ1-3-R) with α1-3-linkage. FUT3 has not only α1,3-fucosyltransferase activity but also α1,4-fucosyltransferase activity (i.e., activity toward type 1 lactosamine structure, Galβ1-3GlcNAcβ1-3-R), and it is proved in polymophism analysis that FUT3 is indispensable for synthesis of Lewis blood group antigen. In addition, FUT3 has activity to transfer fucose to GlcNAc of sialylated lactosamine structure (NeuAcα2-3Galβ1-3GlcNAcβ1-3-R or NeuAcα2-3Galβ1-4GlcNAcβ1-3-R) with α1-3-linkage; therefore, it is related to sialyl Lewis antigen. Sialyl Lewis a (sLea) antigen is synthesized by FUT3 only. FUT3 is known to be involved in synthesis of many Lewis blood group carbohydrate antigens (Lea, Leb, sLea, Lex, Ley, sLex). FUT3 is known with many polymorphism, some of which have no activity.
Lewis Blood group Lewis enzyme histoblood group antigen

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN