GlycoGene DataBase

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JCGG-STR033542 JCGG-STR033543
JCGG-STR002937 JCGG-STR022315
JCGG-STR021541 JCGG-STR022093
JCGG-STR013782 JCGG-STR025761
JCGG-STR021875 JCGG-STR022421
JCGG-STR025525 JCGG-STR003256
JCGG-STR031527 JCGG-STR003144
This gene encodes α1,3-fucosyltransferase 3 (FUT3). Six α1,3-fucosyltransferases (α3FUT): FUT3, FUT4, FUT5, FUT6, FUT7, and FUT9 are known and confirmed that each has specific substrate specificity in vitro. Except FUT7, these have activity to transfer fucose to GlcNAc of the type-2 lactosamine structure (Galβ1-4GlcNAcβ1-3-R) with α1-3-linkage. FUT3 has not only α1,3-fucosyltransferase activity but also α1,4-fucosyltransferase activity (i.e., activity toward type 1 lactosamine structure, Galβ1-3GlcNAcβ1-3-R), and it is proved in polymophism analysis that FUT3 is indispensable for synthesis of Lewis blood group antigen. In addition, FUT3 has activity to transfer fucose to GlcNAc of sialylated lactosamine structure (NeuAcα2-3Galβ1-3GlcNAcβ1-3-R or NeuAcα2-3Galβ1-4GlcNAcβ1-3-R) with α1-3-linkage; therefore, it is related to sialyl Lewis antigen. Sialyl Lewis a (sLea) antigen is synthesized by FUT3 only. FUT3 is known to be involved in synthesis of many Lewis blood group carbohydrate antigens (Lea, Leb, sLea, Lex, Ley, sLex). FUT3 is known with many polymorphism, some of which have no activity.
Lewis Blood group Lewis enzyme histoblood group antigen


Alias LE, Les, CD174, MGC131739    details
Designationalpha1,3/4-fucosyltransferase 3
OrganismHomo sapiens
GeneID 2525
HGNC 4014
mRNA NM_000149       (CDS)
Protein NP_000140       (CDS)
CAZy GT10   
OMIM 111100   
This page does not indicate all of the enzymatic reaction, and expression of "FUT3".