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JCGG-STR027036 JCGG-STR033543
JCGG-STR002937 JCGG-STR022315
JCGG-STR000638 JCGG-STR024242
JCGG-STR001961 JCGG-STR027869
JCGG-STR013782 JCGG-STR025761
JCGG-STR014102 JCGG-STR003144
JCGG-STR021541 JCGG-STR022093
This gene encodes α1,3 fucosyl transferase 5 (FUT5). Six α1,3-fucosyltransferases (α3FUT): FUT3, FUT4, FUT5, FUT6, FUT7, and FUT9 are known and confirmed that each enzyme has a characteristic substrate specificity in vitro. In the enzyme assay of recombinant protein, it was found that FUT5 has activity to transfer fucose to GlcNAc of type-1 lactosamine structure (Galβ1-3GlcNAcβ1-3-R) and type-2 lactosamine structure (Galβ1-4GlcNAcβ1-3-R) with α1-3-linkage, regardless of the presence of terminal sialic acid. The activity on type-2 lactosamine structure is stronger than that on type-1 lactosamine structure. In VIM2 antigen synthesis, fucosyltransferase activity prefers the internal GlcNAc (reducing end) residue rather than the penultimate GlcNAc (internal GlcNAc) residue. The amino acid sequence of FUT5 is highly homologous to that of FUT3 (91%), but the expression of FUT5 is quite localized and rarely found in tissue or cells. Accordingly, biological significance of FUT5 is not clarified.
Lewis blood group Lewis x histoblood group antigen sialyl Lewis x


Alias FUC-TV    details
Designationalpha1,3-fucosyltransferase 5
OrganismHomo sapiens
GeneID 2527
HGNC 4016
mRNA NM_002034       (CDS)
Protein NP_002025       (CDS)
CAZy GT10   
OMIM 136835   
This page does not indicate all of the enzymatic reaction, and expression of "FUT5".