ST3GAL5

JCGG-STR001961		JCGG-STR005020

ST3GAL5, β-galactoside α-2,3-sialyltransferase 5, transfers sialic acid from CMP-sialic acid to the Galβ1→3Glc-Cer on glycolipids. ST3GAL5 is also called as GM3 synthase, SATI or SIAT9. Loss of fuction of ST3GAL5 causes a disruption of ganglioside biosynthesis, resulting in human diseases such as symptomatic epilepsy syndrome and salt-and-pepper syndrome. ST3GAL5-deficient mice demonstrated that GM3 ganglioside is involved in insulin signaling and hearing.
GM3 ganglioside

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN