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ST8SIA1
JCGG-STR005020 JCGG-STR003473
JCGG-STR003473 JCGG-STR033508
ST8SIA1, ST8 α-N-acetylneuraminide α-2,8-sialyltransferase 1, transfers sialic acid from CMP-sialic acid to the NeuAcα2→3Galβ1→4Glc-Cer (GM3). ST8SIA1 is also called as GD3/GT3 synthase or SIAT8A. ST8SIA1-deficient ES cells do not synthesize b-series gangliosides. Double deficient mice of ST8SIA1 and B4GALNT1 express GM3 as the major ganglioside and exhibited lethal audiogenic seizures.
GD3 GT3 ganglioside

Sialyltransferase

GGDB SymbolST8SIA1
Alias SAT-II, GD3S, SIAT8, SIAT8A, ST8SiaI, ST8Sia I    details
DesignationST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
OrganismHomo sapiens
GeneID 6489
HGNC 10869
mRNA NM_003034       (CDS)
Protein NP_003025       (CDS)
map12p12.1-p11.2
EC# 2.4.99.8   
CAZy GT29   
OMIM 601123   

Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)

Expression

Biological Resources
This page does not indicate all of the enzymatic reaction, and expression of "ST8SIA1".