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ST8SIA4
JCGG-STR014102 JCGG-STR033514
JCGG-STR013995 JCGG-STR033515
ST8SIA4, ST8 α-N-acetylneuraminide α-2,8-sialyltransferase4, transfers sialic acid from CMP-sialic acid to the NeuAcα2→3-R and NeuAcα2→6-R structure on glycoproteins, mainly on the neural cell adhesion molecule (NCAM), synthesizing homopolymer of α2,8-linked sialic acid called polysialic acid. ST8SIA4 also synthesizes polysialic acid on O-glycans of Neuropilin-2 (NRP2). ST8SIA4 is also known as PST, SIAT8D, or ST8Sia-IV. Lack of ST8SIA4 impaired long-term potentiation and long-term depression in adult mice. Loss of polysialic acid by double knockout of ST8SIA2 and ST8SIA4 results in early neonatal lethal.

NCAM cell migration neural development polysialic acid

Sialyltransferase

GGDB SymbolST8SIA4
Alias PST, PST1, SIAT8D, MGC34450, MGC61459, ST8SIA-IV    details
DesignationST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
OrganismHomo sapiens
GeneID 7903
HGNC 10871
mRNA NM_005668       (CDS)
Protein NP_005659       (CDS)
map5q21
EC#
CAZy GT29   
OMIM 602547   

Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)

Expression

Biological Resources
This page does not indicate all of the enzymatic reaction, and expression of "ST8SIA4".