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JCGG-STR026907 JCGG-STR003244
GBGT1 encodes globoside alpha-1,3-N-acetylgalactosaminyltransferase 1, which is a Forssman glycolipid synthase involved in the synthesis of the Forssman heterophilic glycolipid antigen (GalNAca1-3GalNAcb1-3Gala1-4Galb1-4Glc-Cer). However in primates including human, GBGT1 has point mutation and thus lacks the enzyme activity (Forssman heterophilic glycolipid antigen negative). On the other hand in other species such as canine and mouse, GBGT1 has enzyme activity and Forssman heterophilic glycolipid antigen is expressed. Forssman heterophilic glycolipid antigen is known to have a function as an accepter of many pathogens.
Forssman heterophilic glycolipid antigen globoside


Alias FS, A3GALNT, UNQ2513, MGC44848, RP11-326L24.6    details
DesignationForssman synthetase, globoside alpha1,3-N-acetylgalactosaminyltransferase
OrganismHomo sapiens
GeneID 26301
HGNC 20460
mRNA NM_021996       (CDS)
Protein NP_068836       (CDS)
CAZy GT6   
OMIM 606074   
This page does not indicate all of the enzymatic reaction, and expression of "GBGT1".