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HO-Ser/Thr GalNAc(alpha1-O)-Ser/Thr
This enzyme catalyzes the GalNAc transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT2 is the second member of this enzyme family. In general, this isozyme exhibits strong activities toward some mucin-box-peptides including Pro-rich sequence, for example IgA-hinge peptide. The substrate specificity was clearly explained with the crystal structure (Fritz et al. 2006).
IgA-hinge peptide O-glycan Tn-antigen mucin proline

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

Alias GalNAc-T2    details
DesignationUDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 2
OrganismHomo sapiens
GeneID 2590
HGNC 4124
mRNA NM_004481       (CDS)
Protein NP_004472       (CDS)
CAZy GT27   
OMIM 602274   
This page does not indicate all of the enzymatic reaction, and expression of "GALNT2".