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HO-Ser/Thr (Glycopeptide) GalNAc(alpha1-O)-Ser/Thr (Glycopeptide)
This enzyme catalyzes the GalNAc-transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT4 is the fourth member of this enzyme family. This exhibits strong activities toward GalNAc-glycosylated peptide produced by GALNT2.

O-glycan Tn-antigen mucin tumor marker

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

Alias GalNAcT4, GALNAC-T4    details
DesignationUDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4
OrganismHomo sapiens
GeneID 8693
HGNC 4126
mRNA NM_003774       (CDS)
Protein NP_003765       (CDS)
CAZy GT27   
OMIM 603565   
This page does not indicate all of the enzymatic reaction, and expression of "GALNT4".