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HO-Ser/Thr GalNAc(alpha1-O)-Ser/Thr
This enzyme catalyzes the GalNAc-transfer from UDP-GalNAc to Ser or Thr residue in the protein. The product is GalNAc-alpha-O-Ser/Thr structure, so-called Tn-antigen, which is the base structure of mucin type O-glycan. The acceptor substrate (protein) is typically Mucin. GALNT5 is the fifth member of this enzyme family. The stem region of this isozyme is uniquely longer than those of other members of this enzyme family.

O-glycan Tn-antigen mucin tumor marker

UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase

Alias GALNAC-T5    details
DesignationUDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 5
OrganismHomo sapiens
GeneID 11227
HGNC 4127
mRNA NM_014568       (CDS)
Protein NP_055383       (CDS)
CAZy GT27   
OMIM 615129   
This page does not indicate all of the enzymatic reaction, and expression of "GALNT5".