B4GALNT3

JCGG-STR008276		JCGG-STR029533

β1,4-N-acetylgalactosaminyltransferase-III (B4GALNT3) transfers GalNAc from UDP-GalNAc to GlcNAcβ-R, synthesizing N,N'-diacetyllactosamine, GalNAcβ1→4GlcNAc (LacdiNAc) on N- and O-glycans. B4GALNT3 is also known as B4GalNac-T3. LacdiNAc structures are also synthesized by its homologue B4GALNT4, and occur on various glycoproteins including lutropin (LH), thyrotropin (TSH), zona pellucida 3 (ZP3), and extracellular matrix glycoproteins. LDN can be further modified with sulfation, sialylation, and fucosylation, indicating important roles of LacdiNAc structures in vivo.

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN