B4GALNT4

JCGG-STR008276		JCGG-STR029533

β1,4-N-acetylgalactosaminyltransferase-IV (B4GALNT4) transfers GalNAc from UDP-GalNAc to GlcNAcβ-R, synthesizing N,N'-diacetyllactosamine, GalNAcβ1→4GlcNAc (LacdiNAc) on N- and O-glycans. B4GALNT4 is also known as B4GalNac-T4 and NGalNAc-T1. Both B4GALNT3 and B4GALNT4 can synthesize LacdiNAc structures, which occur on various glycoproteins including lutropin (LH), thyrotropin (TSH), zona pellucida 3 (ZP3), and extracellular matrix glycoproteins. Expression patterns of two glycosyltransferases are different each other.

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN