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JCGG-STR025711 JCGG-STR029201
GCNT1 is a glucosaminyl (N-acetyl) transferase 1, core 2, which transfers GlcNAc from UDP-GlcNAc to the C6 position of GalNAc in core 1 O-glycan structure, Galβ1→3GalNAc-Ser/Thr, resulting in core 2 structure, Galβ1→3(GlcNAcβ1→6)GalNAc-Ser/Thr. GCNT1 is also known as core 2β1,6 N-acetylglucosaminyltransferase-I, C2GNT1 or C2GNT-L. Core 2 O-glycan is one of key structures in mucin type O-glycans. Overexpression of GCNT1 in resting T-cells reduced immune response by affecting T-B cell interaction. Lack of GCNT1 demonstrated that GCNT1 is partly involved in leukocyte rolling.
O-glycan core 2 mucin


Alias G6NT, C2GNT, C2GNT1, NACGT2, NAGCT2, C2GNT-L, MGC126335, MGC126336    details
Designationglucosaminyl (N-acetyl) transferase 1, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
OrganismHomo sapiens
GeneID 2650
HGNC 4203
mRNA NM_001490       (CDS)
Protein NP_001481       (CDS)
CAZy GT14   
OMIM 600391   
This page does not indicate all of the enzymatic reaction, and expression of "GCNT1".