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MGAT2
JCGG-STR009312 JCGG-STR009224
β1,4-N-Acetylglucosaminyltransferase-II (MGAT2) transfers GlcNAc to β1-2 of Manα1-6(GlcNAcβ1-2Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1-Asn, which is generated by mannosidase taking two mannoses from Manα1-6(Manα1-3)Manα1-6(GlcNAcβ1-2Manα1-3)Manβ1-4GlcNAcβ1-4GlcNAcβ1-Asn synthesized by MGAT1, and synthesizes the GlcNAcb1-2Mana1-6(GlcNAcb1-2Mana1-3)Manb1-4GlcNAcb1-4GlcNAcb1-Asn structure. Mgat2-deficient mice show reduction of N-linked glycans including N-acetyllactosamine and result in lethality after birth.
CDGS2 GLCNACTII GNT-II GNT2

N-Acetylglucosaminyltransferase

GGDB SymbolMGAT2
Alias GNT2, CDGS2, GNT-II, GLCNACTII    details
Designationmannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
OrganismHomo sapiens
GeneID 4247
HGNC 7045
mRNA NM_002408       (CDS)
Protein NP_002399       (CDS)
map14q21
EC# 2.4.1.143   
CAZy GT16   
OMIM 602616   

Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)

Expression

Biological Resources
This page does not indicate all of the enzymatic reaction, and expression of "MGAT2".