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dolichol-phosphate dolichol-phosphate-mannose
DPM1 encodes the catalytic subunit of dolichyl-phosphate mannosyltransferase. Dolichol-phosphate-mannose is required for the synthesis of lipid-linked oligosaccharides and glycosylphosphatidylinositol anchor in the endoplasmic reticulum. Dolichyl-phosphate mannosyltransferase consists of three subunits, DPM1, DPM2 and DPM3. GDP-mannose and dolichol-phosphate are used as donor and acceptor substrates, respectively. Mutation of DPM1 is associated with congenital disorder of glycosylation type 1E.
congenital disorders of glycosylation dolichol-phosphate-mannose


Alias MPDS, CDGIE    details
Designationdolichol-phosphate mannosyltransferase polypeptide 1, catalytic subunit
OrganismHomo sapiens
GeneID 8813
HGNC 3005
mRNA NM_003859       (CDS)
Protein NP_003850       (CDS)
CAZy GT2   
OMIM 603503   
This page does not indicate all of the enzymatic reaction, and expression of "DPM1".