ALG1 encodes beta-1,4-mannosyltransferase that is involved in the synthesis of lipid-linked oligosaccharides in the endoplasmic reticulum. GDP-mannose and chitobiosyldiphosphodolichol are used as donor and acceptor substrates, respectively. ALG1 complements the defect of the yeast alg1 mutant. Mutation of ALG1 is associated with congenital disorder of glycosylation type 1K.
congenital disorders of glycosylation
This page does not indicate all of the enzymatic reaction, and expression of "ALG1".