Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

• Congenital, Hereditary, and Neonatal Diseases and Abnormalities related to Glycans
  • Genetic Diseases, Inborn
    • Metabolism, Inborn Errors
      • Carbohydrate Metabolism, Inborn Errors (synthesis)
        • Pathogenesis
          • Genetic disorders of glycan synthesis (traditional nomenclature)
            • Defects in N-glycan biosynthesis
              • Disorders of N-linked glycosylation - Congenital disorders of glycosylation (CDGs)
                • Type II CDGs
                  • CDG-IIg [COG1]
          • Genetic disorders of glycan synthesis (new nomenclature)
            • Congenital disorders of glycosylation (CDGs)
              • Defects in multiple glycosylation and other pathways
                • Defects in vesicular transport
                  • Defects in COG protein complex
                    • COG1-CDG [COG1]
        • Hereditary disorders by systems
          • Genetic disorders of glycan synthesis (by systems, signs and symptoms)
            • Diseases
              • Cardiovascular Diseases
                • Cardiovascular Abnormalities
                  • Heart Defects, Congenital
                    • COG1-CDG [COG1]
              • Digestive System Diseases
                • Liver Diseases
                  • Hepatomegaly
                    • COG1-CDG [COG1]
              • Hemic and Lymphatic Diseases
                • Lymphatic Diseases
                  • Splenic Diseases
                    • COG1-CDG [COG1]
              • Musculoskeletal Diseases
                • Bone Diseases
                  • Bone Diseases, Developmental
                    • Dwarfism
                      • COG1-CDG [COG1]
                  • Bone Diseases, Metabolic
                    • Osteoporosis
                      • COG1-CDG [COG1]
                  • Spinal Diseases
                    • Spinal Curvatures
                      • COG1-CDG [COG1]
                    • Spondylosis
                      • COG1-CDG [COG1]
                • Musculoskeletal Abnormalities
                  • Craniofacial Abnormalities
                    • Maxillofacial Abnormalities
                      • COG1-CDG [COG1]
                      • Jaw Abnormalities
                        • Micrognathism
                          • COG1-CDG [COG1]
                    • Microcephaly
                      • COG1-CDG [COG1]
              • Nervous System Diseases
                • Nervous System Malformations
                  • Malformations of Cortical Development
                    • Microcephaly
                      • COG1-CDG [COG1]
                • Neurodegenerative Diseases
                  • Heredodegenerative Disorders, Nervous System
                    • COG1-CDG [COG1]
                • Neurologic Manifestations
                  • Neurobehavioral Manifestations
                    • Psychomotor Disorders
                      • COG1-CDG [COG1]
                    • Intellectual Disability
                      • COG1-CDG [COG1]
                  • Neuromuscular Manifestations
                    • Muscle Hypotonia
                      • COG1-CDG [COG1]
              • Pathological Conditions, Signs and Symptoms
                • Pathologic Processes
                  • Growth Disorders
                    • COG1-CDG [COG1]
                • Signs and Symptoms
                  • Failure to Thrive
                    • COG1-CDG [COG1]
              • Stomatognathic Diseases
                • Stomatognathic System Abnormalities
                  • Maxillofacial Abnormalities
                    • Jaw Abnormalities
                      • Micrognathism
                        • COG1-CDG [COG1]
            • Psychiatry and Psychology
              • Mental Disorders
                • Mental Disorders Diagnosed in Childhood
                  • Developmental Disabilities
                    • COG1-CDG [COG1]
                  • Feeding and Eating Disorders of Childhood
                    • COG1-CDG [COG1]
                  • Motor Skills Disorders
                    • COG1-CDG [COG1]
                  • Intellectual Disability
                    • COG1-CDG [COG1]