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GG Family GG Family pathway class N-glycan ALG1 ALG2 ALG3 ALG5 ALG6 ALG8 ALG9 ALG10 ALG11 ALG12 ALG13 ALG14 B4GALT1 B4GALT2 B4GALT3 B3GNT8 B4GALNT2 DPAGT1 DPM1 DPM2 DPM3 FUT8 FUT10 MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT5 MGAT5B ST6GAL1 ST6GAL2 ST8SIA2 ST8SIA3 ST8SIA4 CHST8 CHST9 UGGT1 (UGCGL1) UGGT2 (UGCGL2) O-glycan, mucin-type B3GNT6 B4GALT5 A4GNT B4GALNT2 C1GALT1 C1GALT1C1 GALNT1 GALNT2 GALNT3 GALNT4 GALNT5 GALNT6 GALNT7 GALNT8 GALNT9 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT15 GALNT16 GALNT17 GALNT18 GALNT19 GALNT20 GCNT1 GCNT3 GCNT4 ST3GAL1 ST3GAL2 ST6GALNAC1 ST6GALNAC2 ST8SIA4 ST8SIA6 O-glycan, not mucin-type B3GLCT B3GAT1 B3GAT2 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B3GALNT2 CHST10 EOGT FKTN FKRP FUT4 FUT7 FUT9 GYLTL1B GXYLT1 GXYLT2 LARGE LFNG MGAT5B MFNG OGT POMT1 POMT2 POFUT1 POFUT2 POGLUT1 POMGNT1 RFNG ST3GAL5 ST6GAL1 ST6GAL2 XXYLT1 LFNG MFNG RFNG POMGNT2 POMK Glycosaminoglycan, chondroitin sulfate B3GALT6 B3GAT3 B4GALT7 CHPF CHPF2 CHST3 CHST7 CHST11 CHST12 CHST13 CHST14 CHST15 CHSY1 CHSY3 CSGALNACT1 CSGALNACT2 UST XYLT1 XYLT2 Glycosaminoglycan, heparan sulfate B3GAT3 B3GALT6 B4GALT7 EXT1 EXT2 EXTL1 EXTL2 EXTL3 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 HS6ST1 HS6ST2 HS6ST3 NDST1 NDST2 NDST3 NDST4 XYLT1 XYLT2 Glycosaminoglycan, keratan sulfate B4GAT1 B3GNT2 B3GNT7 B4GALT1 B4GALT2 B4GALT3 B4GALT4 CHST1 CHST2 CHST4 CHST5 CHST6 FUT8 ST3GAL1 ST3GAL2 ST3GAL3 GPI-anchor DPM2 GAA1 PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PGIX PIGY PIGZ glycolipid, lacto/neolacto series A(ABO) B(ABO) B3GALT1 B3GALT2 B3GALT5 B4GAT1 B3GNT2 B3GNT3 B3GNT4 B3GNT5 B4GALT1 B4GALT2 B4GALT3 B4GALT4 FUT1 FUT2 FUT3 FUT4 FUT5 FUT6 FUT7 FUT9 GCNT2 ST3GAL3 ST3GAL4 ST3GAL6 ST8SIA1 glycolipid, ganglio series B3GALT4 B4GALNT1 B4GALNT2 ST3GAL1 ST3GAL2 ST3GAL5 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 ST8SIA1 ST8SIA3 ST8SIA5 glycolipid, globo series A4GALT B3GALT5 B3GALNT1 FUT1 FUT2 FUT9 GBGT1 ST3GAL1 ST3GAL2 ST8SIA1 Hyaluronic acid HAS1 HAS2 HAS3 sphingolipid B4GALT6 GAL3ST1 UGT8 UGCG SLC/transporter SLC35A1 SLC35A2 SLC35A3 SLC35B1 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35D1 SLC35D2 terminal modification B4GALNT3 B4GALNT4 GAL3ST2 GAL3ST3 GAL3ST4 unassign FUT11 additional SFT2 SFT3 COLGALT2 MGAT4C LHL2 L5 HS3ST6 COLGALT1 L4_nuc B3GNT9 SFT9 A3GALT2 UGT3A1 GCNT7 ALG10B ALG1L ALG1L2 SEC1P C5 TMEM5 ART1 Enzymatic Activity ALG Doner Synthesis Dol-P-Man Synthesis DPM1 DPM2 DPM3 Dol-P-Glc Synthesis ALG5 Cytoplasmic ALG(GnT) ALG14 DPAGT1 GLT28D1 Cytoplasmic ALG(ManT) ALG1 ALG11 ALG2 ER Lumen ALG(ManT) ALG12 ALG3 ALG9 ER Lumen ALG(GlcT) ALG10 ALG6 ALG8 Glucosyltransferases UGCG UGCGL1 UGCGL2 Xylosyltransferases XYLT1 XYLT2 GXYLT1 GXYLT2 XXYLT1 LARGE GYLTL1B Fucosyltransferases FUT1 FUT2 FUT3 FUT4 FUT5 FUT6 FUT7 FUT8 FUT9 O-Fucosyltansferases POFUT1 POFUT2 Fucosyltransferases (Unknown Activities) FUT10 FUT11 Mannosyltransferases POMT1 POMT2 PIGM PIGX PIGV PIGB PIGZ Galactosyltransferases Ceramide CGT alpha A4GALT B(ABO) beta 1,3 B3GALT1 B3GALT2 B3GALT4 B3GALT5 B3GALT6 C1GALT1 beta 1,4 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 N-Acetylgalactosaminyltransferases beta 1,3 B3GALNT1 B3GALNT2 beta 1,4 B4GALNT1 B4GALNT2 B4GALNT3 B4GALNT4 UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases GALNT1 GALNT2 GALNT3 GALNT4 GALNT5 GALNT6 GALNT7 GALNT8 GALNT9 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT15 GALNT16 GALNT17 GALNT18 GALNT19 GALNT20 alpha 1,3 A(ABO) GBGT1 N-Acetylglucosaminyltransferases alpha 1,4 A4GNT alpha 1,6 PIGQ PIGC PIGA PIGH PIGP PIGY PIGL PIGW beta 1,3 B3GNT1 B3GNT2 B3GNT3 B3GNT4 B3GNT5 B3GNT6 B3GNT7 B3GNT8 beta 1,6 (core2) GCNT1 GCNT3 GCNT4 blood I antigen GCNT2 MGAT family MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT5 MGAT5B O-linked OGT EOGT Protein O-linked fucose b1,3-N-acetylglucosaminyltransferases MFNG LFNG RFNG Protein O-linked mannose b1,2-N-acetylglucosaminyltransferases POMGNT1 Protein O-linked mannose b1,4-N-acetylglucosaminyltransferases POMGNT2 Glucosyltransferase B3GALTL POGLUT1 LARGE GYLTL1B Sialyltransferases beta-Gal alpha 2,3-sialyltransferases ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 beta-Gal alpha 2,6-sialyltransferases ST6GAL1 ST6GAL2 beta-GalNAc alpha 2,6-sialyltransferases ST6GALNAC1 ST6GALNAC2 ST6GALNAC3 ST6GALNAC4 ST6GALNAC5 ST6GALNAC6 alpha NeuAc alpha 2,8-sialyltransferases ST8SIA1 ST8SIA2 ST8SIA3 ST8SIA4 ST8SIA5 ST8SIA6 GAG chondroitin N-Acetylgalactosaminyltransferases ChGn GALNACT-2 N-Acetylgalactosaminyltransferases Glucuronyltransferases GalNAc/GlcA CHPF CHSY1 CSS3 Glucuronyltransferases CSGlcA-T heparan sulfate Glucuronyltransferases N-Acetylglucosaminyltransferases GlcA/GlcNAc EXT1 EXT2 N-Acetylglucosaminyltransferases EXTL1 EXTL3 EXTL2 Hyaluronan synthase Glucuronyltransferases N-Acetylglucosaminyltransferases GAG GlcA/GlcNAc HAS1 HAS2 HAS3 Glucuronyltransferases B3GAT1 B3GAT2 B3GAT3 Sulfotransferases HNK CHST10 CHST4 CHST5 dermatan/chondroitin Gal 2-O-sulfotransferase UST Gal 3-O-sulfotransferase GAL3ST1 GAL3ST2 GAL3ST3 GAL3ST4 GalNAc 4-O-sulfotransferase CHST8 CHST9 CHST12 CHST13 CHST11 GalNAc4S 6-O-sulfotransferase GALNAC4S-6ST Keratan sulfate Gal 6-O-sulfotransferase CHST1 CHST3 CHST7 GlcNAc 6-O-sulfotransferase CHST6 CHST2 dermatan sulfate D4ST1 heparan sulfate 2-O-sulfotransferase HS2ST1 3-O-sulfotransferase HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 6-O-sulfotransferase HS6ST1 HS6ST2 HS6ST3 N-deacetylase/N-sulfotransferase NDST1 NDST2 NDST3 NDST4 Nucleotide Sugar Transporters CMP-sialic acid transporter SLC35A1 UDP-galactose transporter SLC35A2 SLC35B1 UDP-GlcNAc transporter SLC35A3 PAPS transporter SLC35B2 UDP-Xyl transporter and UDP-GlcNAc transporter SLC35B4 GDP-fucose transporter SLC35C1 UDP-GlcA transporter and UDP-GalNAc transporter SLC35D1 UDP-GlcNAc transporter SLC35D2 PAPS Transporter SLC35B3 α-Dystroglycan Modification FCMD FKRP GPI EtNP Transferase PIGN PIGO PIGF PIGG GPI Transamidase PIGK GAA1 PIGS PIGT PIGU Others POMK C1GALT1C1 EC class 2.4.1 A(ABO) A4GALT ALG1 ALG12 ALG2 ALG3 ALG5 B(ABO) B3GALNT1 B3GALT4 B3GALT6 B3GLCT B3GAT1 B3GAT2 B3GAT3 B3GNT2 B3GNT3 B3GNT4 B3GNT5 B3GNT6 B4GALNT1 B4GALT1 B4GALT2 B4GALT3 B4GALT4 B4GALT5 B4GALT6 B4GALT7 C1GALT1 C1GALT1C1 CGT CSGALNACT1 CSGALNACT2 CSGlcA-T DPM1 DPM2 DPM3 EXT1 EXT2 EXTL1 EXTL2 EXTL3 FUT1 FUT2 FUT3 FUT4 FUT5 FUT6 FUT7 FUT8 FUT9 GALNT1 GALNT10 GALNT11 GALNT12 GALNT13 GALNT14 GALNT15 GALNT16 GALNT17 GALNT2 GALNT3 GALNT4 GALNT5 GALNT6 GALNT7 GALNT8 GALNT9 GBGT1 GCNT1 GCNT2 GLT28D1 HAS1 HAS2 HAS3 LFNG MFNG MGAT1 MGAT2 MGAT3 MGAT4A MGAT4B MGAT5 MGAT5B PIGA PIGB PIGC PIGH PIGM PIGP PIGQ PIGV PIGX PIGY PIGZ POMT1 POMT2 RFNG UGCG 2.4.2 XYLT1 XYLT2 2.4.99 ST3GAL1 ST3GAL2 ST3GAL3 ST3GAL4 ST3GAL5 ST3GAL6 ST6GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC2 ST6GALNAC4 ST8SIA1 2.7.8 DPAGT1 2.8.2 CHST1 CHST11 CHST12 CHST13 CHST2 CHST3 CHST4 CHST5 CHST6 CHST7 CHST8 CHST9 GAL3ST1 GAL3ST2 GAL3ST3 GAL3ST4 HS2ST1 HS3ST1 HS3ST2 HS3ST3A1 HS3ST3B1 HS3ST4 HS3ST5 NDST1 NDST2 NDST3 NDST4 3.5.1 PIGL Open ALL Close ALL

About GlycoGene DataBase

Significance of GGDB

Glycogene includes genes associated with glycan synthesis such as glycosyltransferase, sugar nucleotide synthases, sugar-nucleotide transporters, sulfotransferases, etc. At present, over 180 human glycogenes were identified, cloned and characterized. In "Construction of GlycoGene Library Project " (April, 2001 - March, 2004), we collected and compiled the data on such glycogenes as GlycoGene Database (GGDB), which is the first database to store information on substrate specificity. GGDB provides necessary information for the analysis of glycogenes.

Present Status of GGDB

The purpose of GlycoGene Database (GGDB, http://riodb.ibase.aist.go.jp/rcmg/ggdb) is to provide users with easy access to the information on glycogenes via website. In GGDB, the following property information of each glycogene are stored in XML format: gene names(gene symbols), enzyme names, DNA sequences, tissue distribution(gene expression), substrate specificities, homologous genes, EC numbers, and external links to various databases. It graphically shows the information such as substrate specificities, etc.

Web Interface of Glycogene Database (GGDB)

Future Perspectives

It is expected that GGDB greatly contributes to improve the efficiency of analysis required for progress in glycobiology. GGDB will be updated to provide more integrated functions for which to display information of enzyme reactions and to link to the mass spectrometry database of glycans. The interface will also be expanded in the future with the addition of other property information, based on users feedbacks. In addition, using data mining technique, we are analyzing the stored data to develop a new tool to predict the substrate specificity for each glycogene.

Acknowledgement

The production of those experimental data is supported by the New Energy and Industrial Technology Development Organization (NEDO). The construction of this database, the network security and Web Application Security are supported by Tsukuba Advanced Computing Center(TACC), AIST.

Disclaimer

Research Center for Medical Glycoscience at AIST does not warrant or assure any legal liability or responsibility for the accuracy, completeness, or usefulness of any information available from this website.