Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

• Congenital, Hereditary, and Neonatal Diseases and Abnormalities related to Glycans
  • Genetic Diseases, Inborn
    • Metabolism, Inborn Errors
      • Lysosomal Storage Diseases (degradation)
        • Pathogenesis
          • Genetic disorders of glycan degradation
            • Disorders of sphingolipid metabolism and other lipid storage disorders
              • Sphingolipidosis
                • Other sphingolipidosis
                  • Sulfatidosis
                    • Metachromatic leukodystrophy
                      • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Hereditary disorders by systems
          • Genetic disorders of glycan degradation (by systems, signs and symptoms)
            • Diseases
              • Eye Diseases
                • Retinal Diseases
                  • Retinal Degeneration
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
              • Musculoskeletal Diseases
                • Muscular Diseases
                  • Muscle Rigidity
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Muscle Spasticity
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Muscle Weakness
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
              • Nervous System Diseases
                • Central Nervous System Diseases
                  • Brain Diseases
                    • Brain Diseases, Metabolic
                      • Brain Diseases, Metabolic, Inborn
                        • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                    • Dementia
                      • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Movement Disorders
                    • Dyskinesias
                      • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                • Demyelinating Diseases
                  • Hereditary Central Nervous System Demyelinating Diseases
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                • Neuromuscular Diseases
                  • Peripheral Nervous System Diseases
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                • Neurologic Manifestations
                  • Dyskinesias
                    • Ataxia
                      • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Gait Disorders, Neurologic
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Neurobehavioral Manifestations
                    • Communication Disorders
                      • Language Disorders
                        • Speech Disorders
                          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                      • Learning Disorders
                        • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                    • Intellectual Disability
                      • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Neuromuscular Manifestations
                    • Muscle Hypertonia
                      • Muscle Rigidity
                        • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                      • Muscle Spasticity
                        • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                    • Muscle Weakness
                      • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                    • Muscular Atrophy
                      • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Paralysis
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Paresis
                    • Paraparesis
                      • Paraparesis, Spastic
                        • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Seizures
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Sensation Disorders
                    • Hearing Disorders
                      • Hearing Loss
                        • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                    • Somatosensory Disorders
                      • Hypesthesia
                        • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                    • Vision Disorders
                      • Blindness
                        • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
              • Otorhinolaryngologic Diseases
                • Ear Diseases
                  • Hearing Disorders
                    • Hearing Loss
                      • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
              • Pathological Conditions, Signs and Symptoms
                • Signs and Symptoms
                  • Mobility Limitation
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Urological Manifestations
                    • Lower Urinary Tract Symptoms
                      • Urinary Incontinence
                        • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
            • Psychiatry and Psychology
              • Behavior and Behavior Mechanisms
                • Behavior
                  • Behavioral Symptoms
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
              • Mental Disorders
                • Mental Disorders Diagnosed in Childhood
                  • Child Behavior Disorders
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Developmental Disabilities
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Motor Skills Disorders
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Communication Disorders
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Intellectual Disability
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
                  • Learning Disorders
                    • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]