Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Metachromatic leukodystrophy, due to saposin B deficiency'  (Integration tree)

Pathogenesis

• Genetic disorders of glycan degradation
  • Disorders of sphingolipid metabolism and other lipid storage disorders
    • Sphingolipidosis
      • Other sphingolipidosis
        • Sulfatidosis
          • Metachromatic leukodystrophy
            • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]

Disorders by systems

• Genetic disorders of glycan degradation (by systems, signs and symptoms)
  • Diseases
    • Eye Diseases
      • Retinal Diseases
        • Retinal Degeneration
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
    • Musculoskeletal Diseases
      • Muscular Diseases
        • Muscle Rigidity
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Muscle Spasticity
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Muscle Weakness
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
    • Nervous System Diseases
      • Central Nervous System Diseases
        • Brain Diseases
          • Brain Diseases, Metabolic
            • Brain Diseases, Metabolic, Inborn
              • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
          • Dementia
            • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Movement Disorders
          • Dyskinesias
            • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
      • Demyelinating Diseases
        • Hereditary Central Nervous System Demyelinating Diseases
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
      • Neuromuscular Diseases
        • Peripheral Nervous System Diseases
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
      • Neurologic Manifestations
        • Dyskinesias
          • Ataxia
            • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Gait Disorders, Neurologic
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Neurobehavioral Manifestations
          • Communication Disorders
            • Language Disorders
              • Speech Disorders
                • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
            • Learning Disorders
              • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
          • Intellectual Disability
            • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Neuromuscular Manifestations
          • Muscle Hypertonia
            • Muscle Rigidity
              • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
            • Muscle Spasticity
              • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
          • Muscle Weakness
            • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
          • Muscular Atrophy
            • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Paralysis
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Paresis
          • Paraparesis
            • Paraparesis, Spastic
              • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Seizures
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Sensation Disorders
          • Hearing Disorders
            • Hearing Loss
              • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
          • Somatosensory Disorders
            • Hypesthesia
              • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
          • Vision Disorders
            • Blindness
              • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
    • Otorhinolaryngologic Diseases
      • Ear Diseases
        • Hearing Disorders
          • Hearing Loss
            • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
    • Pathological Conditions, Signs and Symptoms
      • Signs and Symptoms
        • Mobility Limitation
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Urological Manifestations
          • Lower Urinary Tract Symptoms
            • Urinary Incontinence
              • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
  • Psychiatry and Psychology
    • Behavior and Behavior Mechanisms
      • Behavior
        • Behavioral Symptoms
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Child Behavior Disorders
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Developmental Disabilities
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Motor Skills Disorders
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Communication Disorders
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Intellectual Disability
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]
        • Learning Disorders
          • Metachromatic leukodystrophy, due to saposin B deficiency (GDGDB) [PSAP]