Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

• Congenital, Hereditary, and Neonatal Diseases and Abnormalities related to Glycans
  • Genetic Diseases, Inborn
    • Metabolism, Inborn Errors
      • Carbohydrate Metabolism, Inborn Errors (synthesis)
        • Pathogenesis
          • Genetic disorders of glycan synthesis (traditional nomenclature)
            • Defects in N-glycan biosynthesis
              • Disorders of N-linked glycosylation - Congenital disorders of glycosylation (CDGs)
                • Type I CDGs
                  • CDG-Id (GDGDB) [ALG3]
          • Genetic disorders of glycan synthesis (new nomenclature)
            • Congenital disorders of glycosylation (CDGs)
              • Defects in protein N-glycosylation
                • Defects in lipid-linked oligosaccharide biosynthesis
                  • ALG3-CDG (GDGDB) [ALG3]
        • Hereditary disorders by systems
          • Genetic disorders of glycan synthesis (by systems, signs and symptoms)
            • Diseases
              • Digestive System Diseases
                • Liver Diseases
                  • ALG3-CDG (GDGDB) [ALG3]
              • Eye Diseases
                • Eye Abnormalities
                  • Coloboma
                    • ALG3-CDG (GDGDB) [ALG3]
                • Eye Diseases, Hereditary
                  • Optic Atrophies, Hereditary
                    • ALG3-CDG (GDGDB) [ALG3]
                • Ocular Motility Disorders
                  • Strabismus
                    • ALG3-CDG (GDGDB) [ALG3]
                • Vision Disorders
                  • Blindness
                    • ALG3-CDG (GDGDB) [ALG3]
                  • Vision, Low
                    • ALG3-CDG (GDGDB) [ALG3]
                • Optic Nerve Diseases
                  • Optic Atrophy
                    • Optic Atrophies, Hereditary
                      • ALG3-CDG (GDGDB) [ALG3]
              • Musculoskeletal Diseases
                • Joint Diseases
                  • Contracture
                    • ALG3-CDG (GDGDB) [ALG3]
                • Musculoskeletal Abnormalities
                  • Craniofacial Abnormalities
                    • Maxillofacial Abnormalities
                      • ALG3-CDG (GDGDB) [ALG3]
                    • Microcephaly
                      • ALG3-CDG (GDGDB) [ALG3]
                  • Arthrogryposis
                    • ALG3-CDG (GDGDB) [ALG3]
              • Nervous System Diseases
                • Central Nervous System Diseases
                  • Brain Diseases
                    • Cerebellar Diseases
                      • ALG3-CDG (GDGDB) [ALG3]
                    • Epilepsy
                      • Epilepsy, Generalized
                        • Spasms, Infantile
                          • ALG3-CDG (GDGDB) [ALG3]
                      • ALG3-CDG (GDGDB) [ALG3]
                • Nervous System Malformations
                  • Malformations of Cortical Development
                    • Microcephaly
                      • ALG3-CDG (GDGDB) [ALG3]
                • Neurodegenerative Diseases
                  • Heredodegenerative Disorders, Nervous System
                    • ALG3-CDG (GDGDB) [ALG3]
                • Neurologic Manifestations
                  • Neurobehavioral Manifestations
                    • Psychomotor Disorders
                      • ALG3-CDG (GDGDB) [ALG3]
                    • Communication Disorders
                      • Language Disorders
                        • Speech Disorders
                          • ALG3-CDG (GDGDB) [ALG3]
                    • Intellectual Disability
                      • ALG3-CDG (GDGDB) [ALG3]
                  • Neuromuscular Manifestations
                    • Muscle Hypotonia
                      • ALG3-CDG (GDGDB) [ALG3]
                  • Paresis
                    • Paraparesis
                      • Paraparesis, Spastic
                        • ALG3-CDG (GDGDB) [ALG3]
                  • Sensation Disorders
                    • Vision Disorders
                      • Blindness
                        • ALG3-CDG (GDGDB) [ALG3]
                      • Vision, Low
                        • ALG3-CDG (GDGDB) [ALG3]
                  • Reflex, Abnormal
                    • ALG3-CDG (GDGDB) [ALG3]
                  • Seizures
                    • ALG3-CDG (GDGDB) [ALG3]
                • Cranial Nerve Diseases
                  • Ocular Motility Disorders
                    • Strabismus
                      • ALG3-CDG (GDGDB) [ALG3]
                  • Optic Nerve Diseases
                    • Optic Atrophy
                      • Optic Atrophies, Hereditary
                        • ALG3-CDG (GDGDB) [ALG3]
              • Pathological Conditions, Signs and Symptoms
                • Pathologic Processes
                  • Growth Disorders
                    • ALG3-CDG (GDGDB) [ALG3]
                • Signs and Symptoms
                  • Signs and Symptoms, Digestive
                    • Diarrhea
                      • ALG3-CDG (GDGDB) [ALG3]
                    • Vomiting
                      • ALG3-CDG (GDGDB) [ALG3]
                    • ALG3-CDG (GDGDB) [ALG3]
                  • Failure to Thrive
                    • ALG3-CDG (GDGDB) [ALG3]
            • Psychiatry and Psychology
              • Mental Disorders
                • Mental Disorders Diagnosed in Childhood
                  • Developmental Disabilities
                    • ALG3-CDG (GDGDB) [ALG3]
                  • Intellectual Disability
                    • ALG3-CDG (GDGDB) [ALG3]