Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'CDG-Id' 'ALG3-CDG'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)
  • Defects in N-glycan biosynthesis
    • Disorders of N-linked glycosylation - Congenital disorders of glycosylation (CDGs)
      • Type I CDGs
        • CDG-Id (GDGDB) [ALG3]

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)
  • Congenital disorders of glycosylation (CDGs)
    • Defects in protein N-glycosylation
      • Defects in lipid-linked oligosaccharide biosynthesis
        • ALG3-CDG (GDGDB) [ALG3]

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Digestive System Diseases
      • Liver Diseases
        • ALG3-CDG (GDGDB) [ALG3]
    • Eye Diseases
      • Eye Abnormalities
        • Coloboma
          • ALG3-CDG (GDGDB) [ALG3]
      • Eye Diseases, Hereditary
        • Optic Atrophies, Hereditary
          • ALG3-CDG (GDGDB) [ALG3]
      • Ocular Motility Disorders
        • Strabismus
          • ALG3-CDG (GDGDB) [ALG3]
      • Vision Disorders
        • Blindness
          • ALG3-CDG (GDGDB) [ALG3]
        • Vision, Low
          • ALG3-CDG (GDGDB) [ALG3]
      • Optic Nerve Diseases
        • Optic Atrophy
          • Optic Atrophies, Hereditary
            • ALG3-CDG (GDGDB) [ALG3]
    • Musculoskeletal Diseases
      • Joint Diseases
        • Contracture
          • ALG3-CDG (GDGDB) [ALG3]
      • Musculoskeletal Abnormalities
        • Craniofacial Abnormalities
          • Maxillofacial Abnormalities
            • ALG3-CDG (GDGDB) [ALG3]
          • Microcephaly
            • ALG3-CDG (GDGDB) [ALG3]
        • Arthrogryposis
          • ALG3-CDG (GDGDB) [ALG3]
    • Nervous System Diseases
      • Central Nervous System Diseases
        • Brain Diseases
          • Cerebellar Diseases
            • ALG3-CDG (GDGDB) [ALG3]
          • Epilepsy
            • Epilepsy, Generalized
              • Spasms, Infantile
                • ALG3-CDG (GDGDB) [ALG3]
            • ALG3-CDG (GDGDB) [ALG3]
      • Nervous System Malformations
        • Malformations of Cortical Development
          • Microcephaly
            • ALG3-CDG (GDGDB) [ALG3]
      • Neurodegenerative Diseases
        • Heredodegenerative Disorders, Nervous System
          • ALG3-CDG (GDGDB) [ALG3]
      • Neurologic Manifestations
        • Neurobehavioral Manifestations
          • Psychomotor Disorders
            • ALG3-CDG (GDGDB) [ALG3]
          • Communication Disorders
            • Language Disorders
              • Speech Disorders
                • ALG3-CDG (GDGDB) [ALG3]
          • Intellectual Disability
            • ALG3-CDG (GDGDB) [ALG3]
        • Neuromuscular Manifestations
          • Muscle Hypotonia
            • ALG3-CDG (GDGDB) [ALG3]
        • Paresis
          • Paraparesis
            • Paraparesis, Spastic
              • ALG3-CDG (GDGDB) [ALG3]
        • Sensation Disorders
          • Vision Disorders
            • Blindness
              • ALG3-CDG (GDGDB) [ALG3]
            • Vision, Low
              • ALG3-CDG (GDGDB) [ALG3]
        • Reflex, Abnormal
          • ALG3-CDG (GDGDB) [ALG3]
        • Seizures
          • ALG3-CDG (GDGDB) [ALG3]
      • Cranial Nerve Diseases
        • Ocular Motility Disorders
          • Strabismus
            • ALG3-CDG (GDGDB) [ALG3]
        • Optic Nerve Diseases
          • Optic Atrophy
            • Optic Atrophies, Hereditary
              • ALG3-CDG (GDGDB) [ALG3]
    • Pathological Conditions, Signs and Symptoms
      • Pathologic Processes
        • Growth Disorders
          • ALG3-CDG (GDGDB) [ALG3]
      • Signs and Symptoms
        • Signs and Symptoms, Digestive
          • Diarrhea
            • ALG3-CDG (GDGDB) [ALG3]
          • Vomiting
            • ALG3-CDG (GDGDB) [ALG3]
          • ALG3-CDG (GDGDB) [ALG3]
        • Failure to Thrive
          • ALG3-CDG (GDGDB) [ALG3]
  • Psychiatry and Psychology
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Developmental Disabilities
          • ALG3-CDG (GDGDB) [ALG3]
        • Intellectual Disability
          • ALG3-CDG (GDGDB) [ALG3]