Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

• Congenital, Hereditary, and Neonatal Diseases and Abnormalities related to Glycans
  • Genetic Diseases, Inborn
    • Metabolism, Inborn Errors
      • Carbohydrate Metabolism, Inborn Errors (synthesis)
        • Pathogenesis
          • Genetic disorders of glycan synthesis (traditional nomenclature)
            • Defects in N-glycan biosynthesis
              • Disorders of N-linked glycosylation - Congenital disorders of glycosylation (CDGs)
                • Type I CDGs
                  • CDG-Ik (GDGDB) [ALG1]
          • Genetic disorders of glycan synthesis (new nomenclature)
            • Congenital disorders of glycosylation (CDGs)
              • Defects in protein N-glycosylation
                • Defects in lipid-linked oligosaccharide biosynthesis
                  • ALG1-CDG (GDGDB) [ALG1]
        • Hereditary disorders by systems
          • Genetic disorders of glycan synthesis (by systems, signs and symptoms)
            • Diseases
              • Cardiovascular Diseases
                • Heart Diseases
                  • Cardiomyopathies
                    • ALG1-CDG (GDGDB) [ALG1]
              • Digestive System Diseases
                • Liver Diseases
                  • Hepatomegaly
                    • ALG1-CDG (GDGDB) [ALG1]
                  • ALG1-CDG (GDGDB) [ALG1]
              • Endocrine System Diseases
                • Gonadal Disorders
                  • Hypogonadism
                    • ALG1-CDG (GDGDB) [ALG1]
              • Eye Diseases
                • Vision Disorders
                  • Vision, Low
                    • ALG1-CDG (GDGDB) [ALG1]
              • Female Urogenital Diseases and Pregnancy Complications
                • Female Urogenital Diseases
                  • Urologic Diseases
                    • Kidney Diseases
                      • Nephrosis
                        • Nephrotic Syndrome
                          • ALG1-CDG (GDGDB) [ALG1]
              • Hemic and Lymphatic Diseases
                • Hematologic Diseases
                  • Blood Coagulation Disorders
                    • ALG1-CDG (GDGDB) [ALG1]
                • Lymphatic Diseases
                  • Splenic Diseases
                    • ALG1-CDG (GDGDB) [ALG1]
              • Male Urogenital Diseases
                • Urologic Diseases
                  • Kidney Diseases
                    • Nephrosis
                      • Nephrotic Syndrome
                        • ALG1-CDG (GDGDB) [ALG1]
              • Musculoskeletal Diseases
                • Joint Diseases
                  • Contracture
                    • ALG1-CDG (GDGDB) [ALG1]
                • Musculoskeletal Abnormalities
                  • Craniofacial Abnormalities
                    • Craniofacial Dysostosis
                      • Hypertelorism
                        • ALG1-CDG (GDGDB) [ALG1]
                    • Maxillofacial Abnormalities
                      • ALG1-CDG (GDGDB) [ALG1]
                      • Jaw Abnormalities
                        • Micrognathism
                          • ALG1-CDG (GDGDB) [ALG1]
                    • Microcephaly
                      • ALG1-CDG (GDGDB) [ALG1]
              • Nervous System Diseases
                • Central Nervous System Diseases
                  • Brain Diseases
                    • Cerebellar Diseases
                      • ALG1-CDG (GDGDB) [ALG1]
                    • Epilepsy
                      • ALG1-CDG (GDGDB) [ALG1]
                • Nervous System Malformations
                  • Malformations of Cortical Development
                    • Microcephaly
                      • ALG1-CDG (GDGDB) [ALG1]
                • Neurodegenerative Diseases
                  • Heredodegenerative Disorders, Nervous System
                    • ALG1-CDG (GDGDB) [ALG1]
                • Neurologic Manifestations
                  • Neurobehavioral Manifestations
                    • Psychomotor Disorders
                      • ALG1-CDG (GDGDB) [ALG1]
                  • Neuromuscular Manifestations
                    • Muscle Hypotonia
                      • ALG1-CDG (GDGDB) [ALG1]
                  • Sensation Disorders
                    • Vision Disorders
                      • Vision, Low
                        • ALG1-CDG (GDGDB) [ALG1]
                  • Reflex, Abnormal
                    • ALG1-CDG (GDGDB) [ALG1]
                  • Seizures
                    • ALG1-CDG (GDGDB) [ALG1]
              • Pathological Conditions, Signs and Symptoms
                • Signs and Symptoms
                  • Edema
                    • Hydrops Fetalis
                      • ALG1-CDG (GDGDB) [ALG1]
              • Respiratory Tract Diseases
                • Respiration Disorders
                  • Respiratory Insufficiency
                    • ALG1-CDG (GDGDB) [ALG1]
              • Stomatognathic Diseases
                • Stomatognathic System Abnormalities
                  • Maxillofacial Abnormalities
                    • Jaw Abnormalities
                      • Micrognathism
                        • ALG1-CDG (GDGDB) [ALG1]
              • Immune System Diseases
                • Immunologic Deficiency Syndromes
                  • Dysgammaglobulinemia
                    • ALG1-CDG (GDGDB) [ALG1]
                  • ALG1-CDG (GDGDB) [ALG1]
            • Psychiatry and Psychology
              • Mental Disorders
                • Mental Disorders Diagnosed in Childhood
                  • Developmental Disabilities
                    • ALG1-CDG (GDGDB) [ALG1]