Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

• Congenital, Hereditary, and Neonatal Diseases and Abnormalities related to Glycans
  • Genetic Diseases, Inborn
    • Metabolism, Inborn Errors
      • Carbohydrate Metabolism, Inborn Errors (synthesis)
        • Pathogenesis
          • Genetic disorders of glycan synthesis (traditional nomenclature)
            • Defects in N-glycan biosynthesis
              • Disorders of N-linked glycosylation - Congenital disorders of glycosylation (CDGs)
                • Type II CDGs
                  • CDG-IIb (GDGDB) [GCS1]
          • Genetic disorders of glycan synthesis (new nomenclature)
            • Congenital disorders of glycosylation (CDGs)
              • Defects in protein N-glycosylation
                • Defects in N-glycosylation
                  • Defects in N-glycan trimming
                    • GCS1-CDG (GDGDB) [GCS1]
        • Hereditary disorders by systems
          • Genetic disorders of glycan synthesis (by systems, signs and symptoms)
            • Diseases
              • Digestive System Diseases
                • Liver Diseases
                  • Hepatomegaly
                    • GCS1-CDG (GDGDB) [GCS1]
              • Female Urogenital Diseases and Pregnancy Complications
                • Female Urogenital Diseases
                  • Urogenital Abnormalities
                    • GCS1-CDG (GDGDB) [GCS1]
              • Musculoskeletal Diseases
                • Bone Diseases
                  • Spinal Diseases
                    • Spinal Curvatures
                      • Scoliosis
                        • GCS1-CDG (GDGDB) [GCS1]
                • Musculoskeletal Abnormalities
                  • Craniofacial Abnormalities
                    • Maxillofacial Abnormalities
                      • GCS1-CDG (GDGDB) [GCS1]
              • Nervous System Diseases
                • Neurologic Manifestations
                  • Neuromuscular Manifestations
                    • Muscle Hypotonia
                      • GCS1-CDG (GDGDB) [GCS1]
                  • Seizures
                    • GCS1-CDG (GDGDB) [GCS1]
              • Pathological Conditions, Signs and Symptoms
                • Signs and Symptoms
                  • Edema
                    • GCS1-CDG (GDGDB) [GCS1]
              • Respiratory Tract Diseases
                • Respiration Disorders
                  • Apnea
                    • GCS1-CDG (GDGDB) [GCS1]
                  • Respiratory Insufficiency
                    • Hypoventilation
                      • GCS1-CDG (GDGDB) [GCS1]
                    • GCS1-CDG (GDGDB) [GCS1]
            • Psychiatry and Psychology
              • Mental Disorders
                • Mental Disorders Diagnosed in Childhood
                  • Feeding and Eating Disorders of Childhood
                    • GCS1-CDG (GDGDB) [GCS1]