Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

• Congenital, Hereditary, and Neonatal Diseases and Abnormalities related to Glycans
  • Genetic Diseases, Inborn
    • Metabolism, Inborn Errors
      • Carbohydrate Metabolism, Inborn Errors (synthesis)
        • Pathogenesis
          • Genetic disorders of glycan synthesis (traditional nomenclature)
            • Defects in N-glycan biosynthesis
              • Disorders of N-linked glycosylation - Congenital disorders of glycosylation (CDGs)
                • Type II CDGs
                  • CDG-IIi [COG5]
          • Genetic disorders of glycan synthesis (new nomenclature)
            • Congenital disorders of glycosylation (CDGs)
              • Defects in multiple glycosylation and other pathways
                • Defects in vesicular transport
                  • Defects in COG protein complex
                    • COG5-CDG [COG5]
        • Hereditary disorders by systems
          • Genetic disorders of glycan synthesis (by systems, signs and symptoms)
            • Diseases
              • Nervous System Diseases
                • Central Nervous System Diseases
                  • Brain Diseases
                    • Cerebellar Diseases
                      • COG5-CDG [COG5]
                • Neurodegenerative Diseases
                  • Heredodegenerative Disorders, Nervous System
                    • COG5-CDG [COG5]
                • Neurologic Manifestations
                  • Neurobehavioral Manifestations
                    • Communication Disorders
                      • Language Disorders
                        • Speech Disorders
                          • COG5-CDG [COG5]
                          • Articulation Disorders
                            • COG5-CDG [COG5]
                    • Intellectual Disability
                      • COG5-CDG [COG5]
                  • Neuromuscular Manifestations
                    • Muscle Hypotonia
                      • COG5-CDG [COG5]
                  • Dyskinesias
                    • Ataxia
                      • COG5-CDG [COG5]
            • Psychiatry and Psychology
              • Mental Disorders
                • Mental Disorders Diagnosed in Childhood
                  • Motor Skills Disorders
                    • COG5-CDG [COG5]
                  • Intellectual Disability
                    • COG5-CDG [COG5]