Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'CDG-IIi' 'COG5-CDG'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)
  • Defects in N-glycan biosynthesis
    • Disorders of N-linked glycosylation - Congenital disorders of glycosylation (CDGs)
      • Type II CDGs
        • CDG-IIi [COG5]

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)
  • Congenital disorders of glycosylation (CDGs)
    • Defects in multiple glycosylation and other pathways
      • Defects in vesicular transport
        • Defects in COG protein complex
          • COG5-CDG [COG5]

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Nervous System Diseases
      • Central Nervous System Diseases
        • Brain Diseases
          • Cerebellar Diseases
            • COG5-CDG [COG5]
      • Neurodegenerative Diseases
        • Heredodegenerative Disorders, Nervous System
          • COG5-CDG [COG5]
      • Neurologic Manifestations
        • Neurobehavioral Manifestations
          • Communication Disorders
            • Language Disorders
              • Speech Disorders
                • COG5-CDG [COG5]
                • Articulation Disorders
                  • COG5-CDG [COG5]
          • Intellectual Disability
            • COG5-CDG [COG5]
        • Neuromuscular Manifestations
          • Muscle Hypotonia
            • COG5-CDG [COG5]
        • Dyskinesias
          • Ataxia
            • COG5-CDG [COG5]
  • Psychiatry and Psychology
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Motor Skills Disorders
          • COG5-CDG [COG5]
        • Intellectual Disability
          • COG5-CDG [COG5]