Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

• Congenital, Hereditary, and Neonatal Diseases and Abnormalities related to Glycans
  • Genetic Diseases, Inborn
    • Metabolism, Inborn Errors
      • Carbohydrate Metabolism, Inborn Errors (synthesis)
        • Pathogenesis
          • Genetic disorders of glycan synthesis (traditional nomenclature)
            • Disorders of O-linked glycosylation
              • Defects in O-galactosyl glycan biosynthesis
                • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Hereditary disorders by systems
          • Genetic disorders of glycan synthesis (by systems, signs and symptoms)
            • Diseases
              • Cardiovascular Diseases
                • Heart Diseases
                  • Heart Failure
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Heart Valve Diseases
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Vascular Diseases
                  • Aneurysm
                    • Aneurysm, Dissecting
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                    • Aneurysm, Ruptured
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Hemostatic Disorders
                    • Ehlers-Danlos Syndrome
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
              • Eye Diseases
                • Corneal Diseases
                  • Corneal Dystrophies, Hereditary
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Ocular Hypertension
                  • Glaucoma
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Retinal Diseases
                  • Retinal Detachment
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Eye Diseases, Hereditary
                  • Corneal Dystrophies, Hereditary
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Refractive Errors
                  • Myopia
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Ocular Motility Disorders
                  • Strabismus
                    • Esotropia
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Vision Disorders
                  • Blindness
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
              • Hemic and Lymphatic Diseases
                • Hematologic Diseases
                  • Hemorrhagic Disorders
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                    • Hemostatic Disorders
                      • Ehlers-Danlos Syndrome
                        • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
              • Musculoskeletal Diseases
                • Bone Diseases
                  • Spinal Diseases
                    • Spinal Curvatures
                      • Kyphosis
                        • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                      • Scoliosis
                        • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Joint Diseases
                  • Contracture
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Joint Instability
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Musculoskeletal Abnormalities
                  • Craniofacial Abnormalities
                    • Maxillofacial Abnormalities
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Hip Dislocation, Congenital
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Limb Deformities, Congenital
                    • Lower Extremity Deformities, Congenital
                      • Foot Deformities, Congenital
                        • Clubfoot
                          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Muscular Diseases
                  • Muscle Weakness
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
              • Nervous System Diseases
                • Neurologic Manifestations
                  • Gait Disorders, Neurologic
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Neuromuscular Manifestations
                    • Muscle Hypotonia
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                    • Muscular Atrophy
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                    • Muscle Weakness
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Sensation Disorders
                    • Vision Disorders
                      • Blindness
                        • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Reflex, Abnormal
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Neuromuscular Diseases
                  • Peripheral Nervous System Diseases
                    • Polyneuropathy
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Cranial Nerve Diseases
                  • Ocular Motility Disorders
                    • Strabismus
                      • Esotropia
                        • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
              • Pathological Conditions, Signs and Symptoms
                • Pathologic Processes
                  • Growth Disorders
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Pathological Conditions, Anatomical
                  • Hernia
                    • Hernia, Abdominal
                      • Hernia, Inguinal
                        • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Rupture, Spontaneous
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                • Signs and Symptoms
                  • Edema
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Mobility Limitation
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
              • Skin and Connective Tissue Diseases
                • Skin Diseases
                  • Skin Abnormalities
                    • Ehlers-Danlos Syndrome
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
                  • Skin Diseases, Genetic
                    • Ehlers-Danlos Syndrome
                      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
              • Stomatognathic Diseases
                • Stomatognathic System Abnormalities
                  • Tooth Abnormalities
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
              • Wounds and Injuries
                • Dislocations
                  • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
            • Psychiatry and Psychology
              • Mental Disorders
                • Mental Disorders Diagnosed in Childhood
                  • Motor Skills Disorders
                    • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]