Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Ehlers-Danlos syndrome, type VI'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)
  • Disorders of O-linked glycosylation
    • Defects in O-galactosyl glycan biosynthesis
      • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Cardiovascular Diseases
      • Heart Diseases
        • Heart Failure
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Heart Valve Diseases
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Vascular Diseases
        • Aneurysm
          • Aneurysm, Dissecting
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
          • Aneurysm, Ruptured
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Hemostatic Disorders
          • Ehlers-Danlos Syndrome
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
    • Eye Diseases
      • Corneal Diseases
        • Corneal Dystrophies, Hereditary
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Ocular Hypertension
        • Glaucoma
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Retinal Diseases
        • Retinal Detachment
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Eye Diseases, Hereditary
        • Corneal Dystrophies, Hereditary
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Refractive Errors
        • Myopia
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Ocular Motility Disorders
        • Strabismus
          • Esotropia
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Vision Disorders
        • Blindness
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
    • Hemic and Lymphatic Diseases
      • Hematologic Diseases
        • Hemorrhagic Disorders
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
          • Hemostatic Disorders
            • Ehlers-Danlos Syndrome
              • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
    • Musculoskeletal Diseases
      • Bone Diseases
        • Spinal Diseases
          • Spinal Curvatures
            • Kyphosis
              • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
            • Scoliosis
              • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Joint Diseases
        • Contracture
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Joint Instability
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Musculoskeletal Abnormalities
        • Craniofacial Abnormalities
          • Maxillofacial Abnormalities
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Hip Dislocation, Congenital
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Limb Deformities, Congenital
          • Lower Extremity Deformities, Congenital
            • Foot Deformities, Congenital
              • Clubfoot
                • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Muscular Diseases
        • Muscle Weakness
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
    • Nervous System Diseases
      • Neurologic Manifestations
        • Gait Disorders, Neurologic
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Neuromuscular Manifestations
          • Muscle Hypotonia
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
          • Muscular Atrophy
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
          • Muscle Weakness
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Sensation Disorders
          • Vision Disorders
            • Blindness
              • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Reflex, Abnormal
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Neuromuscular Diseases
        • Peripheral Nervous System Diseases
          • Polyneuropathy
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Cranial Nerve Diseases
        • Ocular Motility Disorders
          • Strabismus
            • Esotropia
              • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
    • Pathological Conditions, Signs and Symptoms
      • Pathologic Processes
        • Growth Disorders
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Pathological Conditions, Anatomical
        • Hernia
          • Hernia, Abdominal
            • Hernia, Inguinal
              • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Rupture, Spontaneous
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
      • Signs and Symptoms
        • Edema
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Mobility Limitation
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
    • Skin and Connective Tissue Diseases
      • Skin Diseases
        • Skin Abnormalities
          • Ehlers-Danlos Syndrome
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Skin Diseases, Genetic
          • Ehlers-Danlos Syndrome
            • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
    • Stomatognathic Diseases
      • Stomatognathic System Abnormalities
        • Tooth Abnormalities
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
    • Wounds and Injuries
      • Dislocations
        • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
  • Psychiatry and Psychology
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Motor Skills Disorders
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]