Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

• Congenital, Hereditary, and Neonatal Diseases and Abnormalities related to Glycans
  • Genetic Diseases, Inborn
    • Metabolism, Inborn Errors
      • Carbohydrate Metabolism, Inborn Errors (synthesis)
        • Pathogenesis
          • Genetic disorders of glycan synthesis (traditional nomenclature)
            • Defects in glycolipid synthesis
              • Defects in GPI-anchor biosynthesis
                • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
          • Genetic disorders of glycan synthesis (new nomenclature)
            • Congenital disorders of glycosylation (CDGs)
              • Defects in glycosphingolipid and glycosylphosphatidylinositol anchor glycosylation
                • Disorders of glycosylphosphatidylinositol anchor biosynthesis
                  • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
        • Hereditary disorders by systems
          • Genetic disorders of glycan synthesis (by systems, signs and symptoms)
            • Diseases
              • Cardiovascular Diseases
                • Vascular Diseases
                  • Embolism and Thrombosis
                    • Thrombosis
                      • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
              • Digestive System Diseases
                • Gastrointestinal Diseases
                  • Esophageal Diseases
                    • Deglutition Disorders
                      • Esophageal Motility Disorders
                        • Esophageal Spasm, Diffuse
                          • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
              • Hemic and Lymphatic Diseases
                • Hematologic Diseases
                  • Anemia
                    • Anemia, Hemolytic
                      • Hemoglobinuria, Paroxysmal
                        • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
              • Pathological Conditions, Signs and Symptoms
                • Pathologic Processes
                  • Hemolysis
                    • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
                • Signs and Symptoms
                  • Signs and Symptoms, Digestive
                    • Abdominal Pain
                      • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
                  • Urological Manifestations
                    • Proteinuria
                      • Hemoglobinuria
                        • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
                  • Fatigue
                    • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]