Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION)'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)
  • Defects in glycolipid synthesis
    • Defects in GPI-anchor biosynthesis
      • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)
  • Congenital disorders of glycosylation (CDGs)
    • Defects in glycosphingolipid and glycosylphosphatidylinositol anchor glycosylation
      • Disorders of glycosylphosphatidylinositol anchor biosynthesis
        • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Cardiovascular Diseases
      • Vascular Diseases
        • Embolism and Thrombosis
          • Thrombosis
            • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
    • Digestive System Diseases
      • Gastrointestinal Diseases
        • Esophageal Diseases
          • Deglutition Disorders
            • Esophageal Motility Disorders
              • Esophageal Spasm, Diffuse
                • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
    • Hemic and Lymphatic Diseases
      • Hematologic Diseases
        • Anemia
          • Anemia, Hemolytic
            • Hemoglobinuria, Paroxysmal
              • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
    • Pathological Conditions, Signs and Symptoms
      • Pathologic Processes
        • Hemolysis
          • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
      • Signs and Symptoms
        • Signs and Symptoms, Digestive
          • Abdominal Pain
            • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
        • Urological Manifestations
          • Proteinuria
            • Hemoglobinuria
              • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
        • Fatigue
          • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]