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JCGG-STR031571 JCGG-STR018493
JCGG-STR033534 JCGG-STR033535
JCGG-STR013782 JCGG-STR026619
Initially, 3GnT1 (iGnT; B3GNT1) was isolated by the expression cloning method, and it was reported as an enzyme that transfers GlcNAc to the N-acetyllactosamine structure ([LacNAc: Galβ1-4GlcNAc]), and by further extending, biosynthesizes the poly-N-acetyllactosamine (polylactosamine, [Galβ1-4GlcNAc]n), the structure of which is the repeated structure of the N-acetyllactosamine. However, as it was later reported by “in vitro” experiments, this enzyme is the B4GAT1 enzyme involved in the synthesis of the α-dystroglycan by the transfer a glucuronic acid by the b1-4 linkage. The B4GAT1 enzyme is involved in the synthesis of the structure of GlcA ([GlcAb1-4Xyla1-R), which is the first starting point of the repeating structure of the disaccharide ([GlcAb1-4Xylb1-3]n) synthesized by the LARGE/LARGE2.
poly-N-acetyllactosamine polylactosamine


Alias B3GNT1, iGAT, iGNT, BETA3GNTI    details
DesignationUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
OrganismHomo sapiens
GeneID 11041
HGNC 15685
mRNA NM_006876       (CDS)
Protein NP_006867       (CDS)
CAZy GT49   
OMIM 605517   
This page does not indicate all of the enzymatic reaction, and expression of "B4GAT1".