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The two types of N-acetylgalactosaminyltransferase (GalNAcT) are involved in the biosynthesis of glycan backbone of chondroitin sulfate. One is GalNAcT-I, which catalyzes GalNAc transfer toward GlcA in the linkage region between GAG glycan and proteoglycan core protein and the other is GalNAcT-II, which transfer GalNAc toward GlcA in the repeating di-saccharide unit of (GlcAβ1,3GalNAcβ1,4)n. CSGalNAcT1 and CSGalNAcT2 have both GalNAcT activities in vitro, however, in vivo, they mainly play the GalNAcT-I reaction which is initiation procedure for chondoitin sulfate biosynthesis.
GalNAc transferase chondroitin chondroitin sulfate proteoglycan


Alias ChGn, beta4GalNAcT, UNQ656/PRO1287    details
Designationchondroitin sulfate N-acetylgalactosaminyltransferase 1, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
OrganismHomo sapiens
GeneID 55790
HGNC 24290
mRNA NM_018371       (CDS)
Protein NP_060841       (CDS)
CAZy GT31   
OMIM 616615   
This page does not indicate all of the enzymatic reaction, and expression of "CSGALNACT1".