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The two types of N-acetylgalactosaminyltransferase (GalNAcT) are involved in the biosynthesis of glycan backbone of chondroitin sulfate. One is GalNAcT-I, which catalyzes GalNAc transfer toward GlcA in the linkage region between GAG glycan and proteoglycan core protein and the other is GalNAcT-II, which transfer GalNAc toward GlcA in the repeating di-saccharide unit of (GlcAβ1,3GalNAcβ1,4)n. CSGalNAcT1 and CSGalNAcT2 have both GalNAcT activities in vitro, however, in vivo, they mainly play the GalNAcT-I reaction which is initiation procedure for chondoitin sulfate biosynthesis.
GalNAc transferase chondroitin chondroitin sulfate proteoglycan


Alias CHGN2, PRO0082, CSGalNAcT-2    details
Designationchondroitin sulfate N-acetylgalactosaminyltransferase 2, glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
OrganismHomo sapiens
GeneID 55454
HGNC 24292
mRNA NM_018590       (CDS)
Protein NP_061060       (CDS)
CAZy GT31   
OMIM 616616   
This page does not indicate all of the enzymatic reaction, and expression of "CSGALNACT2".