Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

• Congenital, Hereditary, and Neonatal Diseases and Abnormalities related to Glycans
  • Genetic Diseases, Inborn
    • Metabolism, Inborn Errors
      • Lysosomal Storage Diseases (degradation)
        • Pathogenesis
          • Genetic disorders of glycan degradation
            • Disorders of glycoprotein metabolism
              • Defects in glycoprotein degradation
                • Mannosidase deficiency diseases
                  • Alpha-mannosidosis (GDGDB) [MAN2B1]
                    • Alpha-mannosidosis, type I (early-onset) [MAN2B1]
                    • Alpha-mannosidosis, type II (later-onset) [MAN2B1]
        • Hereditary disorders by systems
          • Genetic disorders of glycan degradation (by systems, signs and symptoms)
            • Diseases
              • Digestive System Diseases
                • Liver Diseases
                  • Hepatomegaly
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Eye Diseases
                • Lens Diseases
                  • Cataract
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Hemic and Lymphatic Diseases
                • Lymphatic Diseases
                  • Splenic Diseases
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Musculoskeletal Diseases
                • Bone Diseases
                  • Bone Diseases, Developmental
                    • Dysostoses
                      • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Bone Diseases, Metabolic
                    • Osteoporosis
                      • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Spinal Diseases
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
                • Joint Diseases
                  • Alpha-mannosidosis (GDGDB) [MAN2B1]
                • Musculoskeletal Abnormalities
                  • Craniofacial Abnormalities
                    • Maxillofacial Abnormalities
                      • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Alpha-mannosidosis (GDGDB) [MAN2B1]
                • Muscular Diseases
                  • Muscle Weakness
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Nervous System Diseases
                • Central Nervous System Diseases
                  • Brain Diseases
                    • Intracranial Hypertension
                      • Hydrocephalus
                        • Alpha-mannosidosis (GDGDB) [MAN2B1]
                • Neurologic Manifestations
                  • Dyskinesias
                    • Ataxia
                      • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Neurobehavioral Manifestations
                    • Communication Disorders
                      • Language Disorders
                        • Speech Disorders
                          • Alpha-mannosidosis (GDGDB) [MAN2B1]
                      • Learning Disorders
                        • Alpha-mannosidosis (GDGDB) [MAN2B1]
                    • Intellectual Disability
                      • Alpha-mannosidosis (GDGDB) [MAN2B1]
                    • Perceptual Disorders
                      • Hallucinations
                        • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Neuromuscular Manifestations
                    • Muscle Weakness
                      • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Sensation Disorders
                    • Hearing Disorders
                      • Hearing Loss
                        • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Otorhinolaryngologic Diseases
                • Ear Diseases
                  • Otitis
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Hearing Disorders
                    • Hearing Loss
                      • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Pathological Conditions, Signs and Symptoms
                • Signs and Symptoms
                  • Mobility Limitation
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Respiratory Tract Diseases
                • Respiratory Tract Infections
                  • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Stomatognathic Diseases
                • Mouth Diseases
                  • Periodontal Diseases
                    • Gingival Diseases
                      • Gingival Overgrowth
                        • Gingival Hyperplasia
                          • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Tongue Diseases
                    • Macroglossia
                      • Alpha-mannosidosis (GDGDB) [MAN2B1]
                • Stomatognathic System Abnormalities
                  • Maxillofacial Abnormalities
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
            • Psychiatry and Psychology
              • Behavior and Behavior Mechanisms
                • Behavior
                  • Behavioral Symptoms
                    • Depression
                      • Alpha-mannosidosis (GDGDB) [MAN2B1]
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
              • Mental Disorders
                • Mental Disorders Diagnosed in Childhood
                  • Anxiety, Separation
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Child Behavior Disorders
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Motor Skills Disorders
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Intellectual Disability
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]
                  • Learning Disorders
                    • Alpha-mannosidosis (GDGDB) [MAN2B1]