GGDonto

GGDonto: Genetic Glyco-Diseases Ontology

Legend:

Concept Types
- target (single disease)
- classification term
- pathway-based classification term
- clinical findings
- multiple types disease
- single disease
- disease type

Genetic disorders of glycan degradation

'Alpha-mannosidosis' (Integration tree)

Pathogenesis

Genetic disorders of glycan degradation
- Disorders of glycoprotein metabolism
  - Defects in glycoprotein degradation
    - Mannosidase deficiency diseases
      - Alpha-mannosidosis (GDGDB) [MAN2B1]
        Alpha-mannosidosis, type I (early-onset) [MAN2B1]
        Alpha-mannosidosis, type II (later-onset) [MAN2B1]

Disorders by systems

Genetic disorders of glycan degradation (by systems, signs and symptoms)
- Diseases
  - Digestive System Diseases
    - Liver Diseases
      - Hepatomegaly
        Alpha-mannosidosis (GDGDB) [MAN2B1]
  - Eye Diseases
    - Lens Diseases
      - Cataract
        Alpha-mannosidosis (GDGDB) [MAN2B1]
  - Hemic and Lymphatic Diseases
    - Lymphatic Diseases
      - Splenic Diseases
        Alpha-mannosidosis (GDGDB) [MAN2B1]
  - Musculoskeletal Diseases
    - Bone Diseases
      - Bone Diseases, Developmental
        Dysostoses
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Bone Diseases, Metabolic
        Osteoporosis
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Spinal Diseases
        Alpha-mannosidosis (GDGDB) [MAN2B1]
    - Joint Diseases
      - Alpha-mannosidosis (GDGDB) [MAN2B1]
    - Musculoskeletal Abnormalities
      - Craniofacial Abnormalities
        Maxillofacial Abnormalities
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Alpha-mannosidosis (GDGDB) [MAN2B1]
    - Muscular Diseases
      - Muscle Weakness
        Alpha-mannosidosis (GDGDB) [MAN2B1]
  - Nervous System Diseases
    - Central Nervous System Diseases
      - Brain Diseases
        Intracranial Hypertension
        Hydrocephalus
        Alpha-mannosidosis (GDGDB) [MAN2B1]
    - Neurologic Manifestations
      - Dyskinesias
        Ataxia
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Neurobehavioral Manifestations
        Communication Disorders
        Language Disorders
        Speech Disorders
        Alpha-mannosidosis (GDGDB) [MAN2B1]
        
        Learning Disorders
        Alpha-mannosidosis (GDGDB) [MAN2B1]
        
        Intellectual Disability
        Alpha-mannosidosis (GDGDB) [MAN2B1]
        
        Perceptual Disorders
        Hallucinations
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Neuromuscular Manifestations
        Muscle Weakness
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Sensation Disorders
        Hearing Disorders
        Hearing Loss
        Alpha-mannosidosis (GDGDB) [MAN2B1]
  - Otorhinolaryngologic Diseases
    - Ear Diseases
      - Otitis
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Hearing Disorders
        Hearing Loss
        Alpha-mannosidosis (GDGDB) [MAN2B1]
  - Pathological Conditions, Signs and Symptoms
    - Signs and Symptoms
      - Mobility Limitation
        Alpha-mannosidosis (GDGDB) [MAN2B1]
  - Respiratory Tract Diseases
    - Respiratory Tract Infections
      - Alpha-mannosidosis (GDGDB) [MAN2B1]
  - Stomatognathic Diseases
    - Mouth Diseases
      - Periodontal Diseases
        Gingival Diseases
        Gingival Overgrowth
        Gingival Hyperplasia
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Tongue Diseases
        Macroglossia
        Alpha-mannosidosis (GDGDB) [MAN2B1]
    - Stomatognathic System Abnormalities
      - Maxillofacial Abnormalities
        Alpha-mannosidosis (GDGDB) [MAN2B1]
- Psychiatry and Psychology
  - Behavior and Behavior Mechanisms
    - Behavior
      - Behavioral Symptoms
        Depression
        Alpha-mannosidosis (GDGDB) [MAN2B1]
        
        Alpha-mannosidosis (GDGDB) [MAN2B1]
  - Mental Disorders
    - Mental Disorders Diagnosed in Childhood
      - Anxiety, Separation
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Child Behavior Disorders
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Motor Skills Disorders
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Intellectual Disability
        Alpha-mannosidosis (GDGDB) [MAN2B1]
      - Learning Disorders
        Alpha-mannosidosis (GDGDB) [MAN2B1]

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