Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

• Congenital, Hereditary, and Neonatal Diseases and Abnormalities related to Glycans
  • Genetic Diseases, Inborn
    • Metabolism, Inborn Errors
      • Carbohydrate Metabolism, Inborn Errors (synthesis)
        • Pathogenesis
          • Genetic disorders of glycan synthesis (traditional nomenclature)
            • Defects in N-glycan biosynthesis
              • Disorders of N-linked glycosylation - Congenital disorders of glycosylation (CDGs)
                • Type I CDGs
                  • CDG-Ih (GDGDB) [ALG8]
          • Genetic disorders of glycan synthesis (new nomenclature)
            • Congenital disorders of glycosylation (CDGs)
              • Defects in protein N-glycosylation
                • Defects in lipid-linked oligosaccharide biosynthesis
                  • ALG8-CDG (GDGDB) [ALG8]
        • Hereditary disorders by systems
          • Genetic disorders of glycan synthesis (by systems, signs and symptoms)
            • Diseases
              • Cardiovascular Diseases
                • Heart Diseases
                  • ALG8-CDG (GDGDB) [ALG8]
              • Digestive System Diseases
                • Gastrointestinal Diseases
                  • Intestinal Diseases
                    • Protein-Losing Enteropathies
                      • ALG8-CDG (GDGDB) [ALG8]
                    • ALG8-CDG (GDGDB) [ALG8]
                • Liver Diseases
                  • Hepatomegaly
                    • ALG8-CDG (GDGDB) [ALG8]
                  • ALG8-CDG (GDGDB) [ALG8]
              • Endocrine System Diseases
                • Thyroid Diseases
                  • Hypothyroidism
                    • ALG8-CDG (GDGDB) [ALG8]
              • Hemic and Lymphatic Diseases
                • Hematologic Diseases
                  • Anemia
                    • ALG8-CDG (GDGDB) [ALG8]
                  • Blood Platelet Disorders
                    • Thrombocytopenia
                      • ALG8-CDG (GDGDB) [ALG8]
                  • Blood Coagulation Disorders
                    • ALG8-CDG (GDGDB) [ALG8]
                  • Blood Protein Disorders
                    • Hypoproteinemia
                      • Hypoalbuminemia
                        • ALG8-CDG (GDGDB) [ALG8]
              • Musculoskeletal Diseases
                • Musculoskeletal Abnormalities
                  • Craniofacial Abnormalities
                    • Maxillofacial Abnormalities
                      • ALG8-CDG (GDGDB) [ALG8]
              • Nervous System Diseases
                • Neurologic Manifestations
                  • Neurobehavioral Manifestations
                    • Psychomotor Disorders
                      • ALG8-CDG (GDGDB) [ALG8]
                  • Neuromuscular Manifestations
                    • Muscle Hypotonia
                      • ALG8-CDG (GDGDB) [ALG8]
                  • Seizures
                    • ALG8-CDG (GDGDB) [ALG8]
              • Pathological Conditions, Signs and Symptoms
                • Signs and Symptoms
                  • Signs and Symptoms, Digestive
                    • Diarrhea
                      • ALG8-CDG (GDGDB) [ALG8]
                    • Vomiting
                      • ALG8-CDG (GDGDB) [ALG8]
              • Respiratory Tract Diseases
                • Lung Diseases
                  • ALG8-CDG (GDGDB) [ALG8]
                • Respiration Disorders
                  • Dyspnea
                    • ALG8-CDG (GDGDB) [ALG8]
            • Psychiatry and Psychology
              • Mental Disorders
                • Mental Disorders Diagnosed in Childhood
                  • Feeding and Eating Disorders of Childhood
                    • ALG8-CDG (GDGDB) [ALG8]