Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'CDG-Ih' 'ALG8-CDG'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)
  • Defects in N-glycan biosynthesis
    • Disorders of N-linked glycosylation - Congenital disorders of glycosylation (CDGs)
      • Type I CDGs
        • CDG-Ih (GDGDB) [ALG8]

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)
  • Congenital disorders of glycosylation (CDGs)
    • Defects in protein N-glycosylation
      • Defects in lipid-linked oligosaccharide biosynthesis
        • ALG8-CDG (GDGDB) [ALG8]

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Cardiovascular Diseases
      • Heart Diseases
        • ALG8-CDG (GDGDB) [ALG8]
    • Digestive System Diseases
      • Gastrointestinal Diseases
        • Intestinal Diseases
          • Protein-Losing Enteropathies
            • ALG8-CDG (GDGDB) [ALG8]
          • ALG8-CDG (GDGDB) [ALG8]
      • Liver Diseases
        • Hepatomegaly
          • ALG8-CDG (GDGDB) [ALG8]
        • ALG8-CDG (GDGDB) [ALG8]
    • Endocrine System Diseases
      • Thyroid Diseases
        • Hypothyroidism
          • ALG8-CDG (GDGDB) [ALG8]
    • Hemic and Lymphatic Diseases
      • Hematologic Diseases
        • Anemia
          • ALG8-CDG (GDGDB) [ALG8]
        • Blood Platelet Disorders
          • Thrombocytopenia
            • ALG8-CDG (GDGDB) [ALG8]
        • Blood Coagulation Disorders
          • ALG8-CDG (GDGDB) [ALG8]
        • Blood Protein Disorders
          • Hypoproteinemia
            • Hypoalbuminemia
              • ALG8-CDG (GDGDB) [ALG8]
    • Musculoskeletal Diseases
      • Musculoskeletal Abnormalities
        • Craniofacial Abnormalities
          • Maxillofacial Abnormalities
            • ALG8-CDG (GDGDB) [ALG8]
    • Nervous System Diseases
      • Neurologic Manifestations
        • Neurobehavioral Manifestations
          • Psychomotor Disorders
            • ALG8-CDG (GDGDB) [ALG8]
        • Neuromuscular Manifestations
          • Muscle Hypotonia
            • ALG8-CDG (GDGDB) [ALG8]
        • Seizures
          • ALG8-CDG (GDGDB) [ALG8]
    • Pathological Conditions, Signs and Symptoms
      • Signs and Symptoms
        • Signs and Symptoms, Digestive
          • Diarrhea
            • ALG8-CDG (GDGDB) [ALG8]
          • Vomiting
            • ALG8-CDG (GDGDB) [ALG8]
    • Respiratory Tract Diseases
      • Lung Diseases
        • ALG8-CDG (GDGDB) [ALG8]
      • Respiration Disorders
        • Dyspnea
          • ALG8-CDG (GDGDB) [ALG8]
  • Psychiatry and Psychology
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Feeding and Eating Disorders of Childhood
          • ALG8-CDG (GDGDB) [ALG8]