Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Bruck syndrome 2'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)
  • Disorders of O-linked glycosylation
    • Defects in O-galactosyl glycan biosynthesis
      • Bruck syndrome 2 (GDGDB) [PLOD2]

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Musculoskeletal Diseases
      • Bone Diseases
        • Bone Diseases, Developmental
          • Osteochondrodysplasias
            • Osteogenesis Imperfecta
              • Bruck syndrome 2 (GDGDB) [PLOD2]
        • Bone Diseases, Metabolic
          • Osteoporosis
            • Bruck syndrome 2 (GDGDB) [PLOD2]
      • Joint Diseases
        • Contracture
          • Bruck syndrome 2 (GDGDB) [PLOD2]
        • Bruck syndrome 2 (GDGDB) [PLOD2]
      • Musculoskeletal Abnormalities
        • Limb Deformities, Congenital
          • Lower Extremity Deformities, Congenital
            • Foot Deformities, Congenital
              • Clubfoot
                • Bruck syndrome 2 (GDGDB) [PLOD2]
        • Arthrogryposis
          • Bruck syndrome 2 (GDGDB) [PLOD2]
    • Pathological Conditions, Signs and Symptoms
      • Pathological Conditions, Anatomical
        • Hernia
          • Hernia, Abdominal
            • Hernia, Inguinal
              • Bruck syndrome 2 (GDGDB) [PLOD2]
    • Skin and Connective Tissue Diseases
      • Connective Tissue Diseases
        • Collagen Diseases
          • Osteogenesis Imperfecta
            • Bruck syndrome 2 (GDGDB) [PLOD2]
    • Wounds and Injuries
      • Fractures, Bone
        • Fractures, Spontaneous
          • Bruck syndrome 2 (GDGDB) [PLOD2]