Legend:

• Concept Types
  • target (clinical findings)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Heart Diseases'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Cardiovascular Diseases
      • Heart Diseases
        • Cardiomegaly
          • Cardiomyopathy, dilated, 1X (GDGDB) [FKTN]
        • Heart Failure
          • DOLK-CDG [TMEM15]
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Heart Valve Diseases
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Cardiomyopathies
          • Endomyocardial Fibrosis
            • Fukuyama congenital muscular dystrophy (GDGDB) [FKTN]
          • PMM2-CDG (GDGDB) [PMM2]
            • PMM2-CDG, infantile multisystem stage [PMM2]
          • ALG1-CDG (GDGDB) [ALG1]
          • DOLK-CDG [TMEM15]
          • Fukuyama congenital muscular dystrophy (GDGDB) [FKTN]
          • Muscular dystrophy, limb-girdle, type 2M (GDGDB) [FKTN]
          • Cardiomyopathy, dilated, 1X (GDGDB) [FKTN]
          • Muscular dystrophy, limb-girdle, type 2I (GDGDB) [FKRP]
          • Duchenne muscular dystrophy [DMD]
          • DPM3-CDG [DPM3]
          • PGM1-CDG [PGM1]
        • Pericardial Effusion
          • PMM2-CDG (GDGDB) [PMM2]
            • PMM2-CDG, infantile multisystem stage [PMM2]
            • PMM2-CDG, late-infantile and childhood ataxia-intellectual disability stage [PMM2]
            • PMM2-CDG, adult stable disability stage [PMM2]
          • ALG9-CDG (GDGDB) [ALG9]
        • Arrhythmias, Cardiac
          • DOLK-CDG [TMEM15]
        • ALG12-CDG (GDGDB) [ALG12]
        • ALG8-CDG (GDGDB) [ALG8]
        • Cardiomyopathy, dilated, 1X (GDGDB) [FKTN]
        • Muscular dystrophy, limb-girdle, type 2I (GDGDB) [FKRP]
        • DPM3-CDG [DPM3]
        • SRD5A3-CDG [SRD5A3]
        • PGM1-CDG [PGM1]
        • Multiple joint dislocations, short stature, craniofacial dysmorphism, and congenital heart defects [B3GAT3]
        • Spondyloepiphyseal dysplasia with congenital joint dislocations [CHST3]
        • Ehlers-Danlos syndrome, musculocontractural type [CHST14]
        • Hyperphosphatasia with mental retardation syndrome 1 [PIGV]
        • Multiple congenital anomalies-hypotonia-seizures syndrome 1 [PIGN]