Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'CDG-Ib' 'MPI-CDG'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)
  • Defects in N-glycan biosynthesis
    • Disorders of N-linked glycosylation - Congenital disorders of glycosylation (CDGs)
      • Type I CDGs
        • CDG-Ib (GDGDB) [MPI]

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)
  • Congenital disorders of glycosylation (CDGs)
    • Defects in protein N-glycosylation
      • Defects in nucleotide-sugar biosynthesis
        • MPI-CDG (GDGDB) [MPI]

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Digestive System Diseases
      • Gastrointestinal Diseases
        • Intestinal Diseases
          • Protein-Losing Enteropathies
            • MPI-CDG (GDGDB) [MPI]
        • Gastrointestinal Hemorrhage
          • MPI-CDG (GDGDB) [MPI]
      • Liver Diseases
        • Hepatomegaly
          • MPI-CDG (GDGDB) [MPI]
        • MPI-CDG (GDGDB) [MPI]
    • Hemic and Lymphatic Diseases
      • Hematologic Diseases
        • Blood Coagulation Disorders
          • MPI-CDG (GDGDB) [MPI]
    • Pathological Conditions, Signs and Symptoms
      • Pathologic Processes
        • Growth Disorders
          • MPI-CDG (GDGDB) [MPI]
        • Hemorrhage
          • Gastrointestinal Hemorrhage
            • MPI-CDG (GDGDB) [MPI]
      • Signs and Symptoms
        • Signs and Symptoms, Digestive
          • Diarrhea
            • MPI-CDG (GDGDB) [MPI]
          • Vomiting
            • MPI-CDG (GDGDB) [MPI]
        • Failure to Thrive
          • MPI-CDG (GDGDB) [MPI]
    • Nutritional and Metabolic Diseases
      • Metabolic Diseases
        • Glucose Metabolism Disorders
          • Hypoglycemia
            • MPI-CDG (GDGDB) [MPI]