Legend:

• Concept Types
  • target (clinical findings)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Hemic and Lymphatic Diseases'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Hemic and Lymphatic Diseases
      • Hematologic Diseases
        • Anemia
          • Anemia, Hemolytic
            • Hemoglobinuria, Paroxysmal
              • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
            • Anemia, Hemolytic, Congenital
              • Anemia, Dyserythropoietic, Congenital
                • SEC23B-CDG (GDGDB) [SEC23B]
            • Anemia, Hemolytic, Autoimmune
              • Tn polyagglutination syndrome, somatic (SOMATIC MUTATION) [C1GALT1C1]
          • ALG8-CDG (GDGDB) [ALG8]
          • DPAGT1-CDG (GDGDB) [DPAGT1]
          • SEC23B-CDG (GDGDB) [SEC23B]
          • SRD5A3-CDG [SRD5A3]
        • Blood Platelet Disorders
          • Thrombocytopenia
            • ALG8-CDG (GDGDB) [ALG8]
            • SLC35A1-CDG [SLC35A1]
            • COG4-CDG [COG4]
            • Tn polyagglutination syndrome, somatic (SOMATIC MUTATION) [C1GALT1C1]
        • Hemorrhagic Disorders
          • SLC35A1-CDG [SLC35A1]
          • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
          • Hemostatic Disorders
            • Ehlers-Danlos Syndrome
              • Ehlers-Danlos syndrome, type VI (GDGDB) (GDGDB) [PLOD1]
        • Blood Coagulation Disorders
          • Coagulation Protein Disorders
            • PMM2-CDG (GDGDB) [PMM2]
              • PMM2-CDG, infantile multisystem stage [PMM2]
              • PMM2-CDG, late-infantile and childhood ataxia-intellectual disability stage [PMM2]
              • PMM2-CDG, adult stable disability stage [PMM2]
            • COG8-CDG [COG8]
            • COG4-CDG [COG4]
            • SRD5A3-CDG [SRD5A3]
            • DDOST-CDG [DDOST]
            • PGM1-CDG [PGM1]
          • PMM2-CDG (GDGDB) [PMM2]
            • PMM2-CDG, infantile multisystem stage [PMM2]
            • PMM2-CDG, late-infantile and childhood ataxia-intellectual disability stage [PMM2]
            • PMM2-CDG, adult stable disability stage [PMM2]
          • MPI-CDG (GDGDB) [MPI]
          • ALG6-CDG (GDGDB) [ALG6]
          • ALG12-CDG (GDGDB) [ALG12]
          • ALG8-CDG (GDGDB) [ALG8]
          • ALG2-CDG (GDGDB) [ALG2]
          • ALG1-CDG (GDGDB) [ALG1]
          • RFT1-CDG [RFT1]
          • MGAT2-CDG (GDGDB) [MGAT2]
          • B4GALT1-CDG (GDGDB) [B4GALT1]
          • COG8-CDG [COG8]
          • COG4-CDG [COG4]
          • SRD5A3-CDG [SRD5A3]
          • COG6-CDG [COG6]
        • Blood Protein Disorders
          • Hypoproteinemia
            • Hypoalbuminemia
              • PMM2-CDG (GDGDB) [PMM2]
                • PMM2-CDG, infantile multisystem stage [PMM2]
              • ALG8-CDG (GDGDB) [ALG8]
            • DPAGT1-CDG (GDGDB) [DPAGT1]
        • Leukocyte Disorders
          • Leukocytosis
            • SLC35C1-CDG (GDGDB) [SLC35C1]
          • Leukopenia
            • Agranulocytosis
              • Neutropenia
                • SLC35A1-CDG [SLC35A1]
            • Tn polyagglutination syndrome, somatic (SOMATIC MUTATION) [C1GALT1C1]
      • Lymphatic Diseases
        • Splenic Diseases
          • ALG1-CDG (GDGDB) [ALG1]
          • ALG9-CDG (GDGDB) [ALG9]
          • COG7-CDG (GDGDB) [COG7]
          • COG1-CDG [COG1]
          • COG4-CDG [COG4]
          • SEC23B-CDG (GDGDB) [SEC23B]
          • PIGM-CDG [PIGM]
          • TMEM165-CDG [TMEM165]