Legend:

• Concept Types
  • target (clinical findings)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Digestive System Diseases'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Digestive System Diseases
      • Gastrointestinal Diseases
        • Esophageal Diseases
          • Deglutition Disorders
            • Esophageal Motility Disorders
              • Esophageal Spasm, Diffuse
                • Paroxysmal nocturnal hemoglobinuria, somatic (SOMATIC MUTATION) (GDGDB) [PIGA]
        • Intestinal Diseases
          • Protein-Losing Enteropathies
            • MPI-CDG (GDGDB) [MPI]
            • ALG6-CDG (GDGDB) [ALG6]
            • ALG8-CDG (GDGDB) [ALG8]
          • ALG8-CDG (GDGDB) [ALG8]
        • Gastrointestinal Hemorrhage
          • MPI-CDG (GDGDB) [MPI]
          • ALG11-CDG [ALG11]
        • COG6-CDG [COG6]
        • Ehlers-Danlos syndrome, musculocontractural type [CHST14]
        • Multiple congenital anomalies-hypotonia-seizures syndrome 1 [PIGN]
      • Liver Diseases
        • Hepatomegaly
          • MPI-CDG (GDGDB) [MPI]
          • ALG8-CDG (GDGDB) [ALG8]
          • ALG2-CDG (GDGDB) [ALG2]
          • ALG1-CDG (GDGDB) [ALG1]
          • ALG9-CDG (GDGDB) [ALG9]
          • RFT1-CDG [RFT1]
          • GCS1-CDG (GDGDB) [GCS1]
          • B4GALT1-CDG (GDGDB) [B4GALT1]
          • COG7-CDG (GDGDB) [COG7]
          • COG1-CDG [COG1]
          • COG4-CDG [COG4]
          • PIGM-CDG [PIGM]
          • ALG13-CDG [ALG13]
          • TMEM165-CDG [TMEM165]
          • COG6-CDG [COG6]
        • Hepatic Insufficiency
          • PMM2-CDG (GDGDB) [PMM2]
        • Hypertension, Portal
          • PIGM-CDG [PIGM]
        • Liver Cirrhosis
          • PMM2-CDG (GDGDB) [PMM2]
            • PMM2-CDG, infantile multisystem stage [PMM2]
          • COG4-CDG [COG4]
          • COG6-CDG [COG6]
        • PMM2-CDG (GDGDB) [PMM2]
        • MPI-CDG (GDGDB) [MPI]
        • ALG3-CDG (GDGDB) [ALG3]
        • ALG8-CDG (GDGDB) [ALG8]
        • ALG1-CDG (GDGDB) [ALG1]
        • SRD5A3-CDG [SRD5A3]
        • DDOST-CDG [DDOST]
        • PGM1-CDG [PGM1]
        • COG6-CDG [COG6]
      • Biliary Tract Diseases
        • Cholelithiasis
          • SEC23B-CDG (GDGDB) [SEC23B]
      • Digestive System Abnormalities
        • Anus, Imperforate
          • Hyperphosphatasia with mental retardation syndrome 1 [PIGV]
          • Multiple congenital anomalies-hypotonia-seizures syndrome 1 [PIGN]
        • COG6-CDG [COG6]
        • Hyperphosphatasia with mental retardation syndrome 1 [PIGV]
        • Multiple congenital anomalies-hypotonia-seizures syndrome 1 [PIGN]