Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Lysyl hydroxylase 3 deficiency'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)
  • Disorders of O-linked glycosylation
    • Defects in O-galactosyl glycan biosynthesis
      • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Cardiovascular Diseases
      • Vascular Diseases
        • Aneurysm
          • Aneurysm, Ruptured
            • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
          • Intracranial Aneurysm
            • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
    • Eye Diseases
      • Lens Diseases
        • Cataract
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
      • Refractive Errors
        • Myopia
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
    • Hemic and Lymphatic Diseases
      • Hematologic Diseases
        • Hemorrhagic Disorders
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
    • Musculoskeletal Diseases
      • Bone Diseases
        • Bone Diseases, Metabolic
          • Osteoporosis
            • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
        • Spinal Diseases
          • Spinal Curvatures
            • Scoliosis
              • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
      • Joint Diseases
        • Contracture
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
      • Musculoskeletal Abnormalities
        • Craniofacial Abnormalities
          • Maxillofacial Abnormalities
            • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
        • Limb Deformities, Congenital
          • Lower Extremity Deformities, Congenital
            • Foot Deformities, Congenital
              • Clubfoot
                • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
        • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
    • Nervous System Diseases
      • Nervous System Malformations
        • Central Nervous System Cysts
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
    • Otorhinolaryngologic Diseases
      • Ear Diseases
        • Hearing Disorders
          • Hearing Loss
            • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
    • Pathological Conditions, Signs and Symptoms
      • Pathologic Processes
        • Growth Disorders
          • Fetal Growth Retardation
            • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
      • Pathological Conditions, Anatomical
        • Rupture, Spontaneous
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
    • Skin and Connective Tissue Diseases
      • Connective Tissue Diseases
        • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
    • Wounds and Injuries
      • Fractures, Bone
        • Fractures, Spontaneous
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]
  • Psychiatry and Psychology
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Developmental Disabilities
          • Lysyl hydroxylase 3 deficiency (GDGDB) [PLOD3]