Legend:

• Concept Types
  • target (clinical findings)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Communication Disorders'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Nervous System Diseases
      • Neurologic Manifestations
        • Neurobehavioral Manifestations
          • Communication Disorders
            • Language Disorders
              • Speech Disorders
                • PMM2-CDG (GDGDB) [PMM2]
                  • PMM2-CDG, infantile multisystem stage [PMM2]
                  • PMM2-CDG, late-infantile and childhood ataxia-intellectual disability stage [PMM2]
                  • PMM2-CDG, adult stable disability stage [PMM2]
                • ALG6-CDG (GDGDB) [ALG6]
                • ALG3-CDG (GDGDB) [ALG3]
                • DPM1-CDG (GDGDB) [DPM1]
                • DPAGT1-CDG (GDGDB) [DPAGT1]
                • COG5-CDG [COG5]
                • COG4-CDG [COG4]
                • POMT1/POMT2-CDG (cong. muscular dystrophy spectrum) (GDGDB) [POMT1,POMT2]
                • POMGNT1-CDG (cong. muscular dystrophy spectrum) (GDGDB) [POMGNT1]
                • Fukuyama congenital muscular dystrophy (GDGDB) [FKTN]
                • ST3GAL5-CDG [SIAT9]
                • Articulation Disorders
                  • COG5-CDG [COG5]
                  • Dysarthria
                    • PMM2-CDG (GDGDB) [PMM2]
                      • PMM2-CDG, infantile multisystem stage [PMM2]
                      • PMM2-CDG, late-infantile and childhood ataxia-intellectual disability stage [PMM2]
                      • PMM2-CDG, adult stable disability stage [PMM2]
                • DDOST-CDG [DDOST]
                • Mental retardation, autosomal recessive 15 [MAN1B1]
                • Hyperphosphatasia with mental retardation syndrome 1 [PIGV]
            • Learning Disorders
              • Temtamy preaxial brachydactyly syndrome [CHSY1]
              • Hyperphosphatasia with mental retardation syndrome 1 [PIGV]