Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'CDG-IIc' 'SLC35C1-CDG'  (Integration tree)

Pathogenesis (traditional nomenclature)

• Genetic disorders of glycan synthesis (traditional nomenclature)
  • Defects in N-glycan biosynthesis
    • Disorders of N-linked glycosylation - Congenital disorders of glycosylation (CDGs)
      • Type II CDGs
        • CDG-IIc (GDGDB) [SLC35C1]

Pathogenesis (new nomenclature)

• Genetic disorders of glycan synthesis (new nomenclature)
  • Congenital disorders of glycosylation (CDGs)
    • Defects in multiple glycosylation and other pathways
      • Defects in nucleotide-sugar transport
        • SLC35C1-CDG (GDGDB) [SLC35C1]

Genetic disorders of glycan synthesis (by systems, signs and symptoms)

• Genetic disorders of glycan synthesis (by systems, signs and symptoms)
  • Diseases
    • Hemic and Lymphatic Diseases
      • Hematologic Diseases
        • Leukocyte Disorders
          • Leukocytosis
            • SLC35C1-CDG (GDGDB) [SLC35C1]
    • Musculoskeletal Diseases
      • Bone Diseases
        • Bone Diseases, Developmental
          • Dwarfism
            • SLC35C1-CDG (GDGDB) [SLC35C1]
      • Musculoskeletal Abnormalities
        • Craniofacial Abnormalities
          • Maxillofacial Abnormalities
            • SLC35C1-CDG (GDGDB) [SLC35C1]
          • Microcephaly
            • SLC35C1-CDG (GDGDB) [SLC35C1]
    • Nervous System Diseases
      • Nervous System Malformations
        • Malformations of Cortical Development
          • Microcephaly
            • SLC35C1-CDG (GDGDB) [SLC35C1]
      • Neurologic Manifestations
        • Neurobehavioral Manifestations
          • Psychomotor Disorders
            • SLC35C1-CDG (GDGDB) [SLC35C1]
          • Intellectual Disability
            • SLC35C1-CDG (GDGDB) [SLC35C1]
        • Neuromuscular Manifestations
          • Muscle Hypotonia
            • SLC35C1-CDG (GDGDB) [SLC35C1]
        • Seizures
          • SLC35C1-CDG (GDGDB) [SLC35C1]
    • Otorhinolaryngologic Diseases
      • Ear Diseases
        • Otitis
          • SLC35C1-CDG (GDGDB) [SLC35C1]
    • Pathological Conditions, Signs and Symptoms
      • Pathologic Processes
        • Growth Disorders
          • SLC35C1-CDG (GDGDB) [SLC35C1]
      • Signs and Symptoms
        • Failure to Thrive
          • SLC35C1-CDG (GDGDB) [SLC35C1]
    • Respiratory Tract Diseases
      • Respiratory Tract Infections
        • SLC35C1-CDG (GDGDB) [SLC35C1]
    • Immune System Diseases
      • Immunologic Deficiency Syndromes
        • Leukocyte-Adhesion Deficiency Syndrome
          • SLC35C1-CDG (GDGDB) [SLC35C1]
        • SLC35C1-CDG (GDGDB) [SLC35C1]
  • Psychiatry and Psychology
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Developmental Disabilities
          • SLC35C1-CDG (GDGDB) [SLC35C1]
        • Intellectual Disability
          • SLC35C1-CDG (GDGDB) [SLC35C1]