Legend:

• Concept Types
  • target (single disease)
  • classification term
  • pathway-based classification term
  • clinical findings
  • multiple types disease
  • single disease
  • disease type

'Hurler syndrome'  (Integration tree)

Pathogenesis

• Genetic disorders of glycan degradation
  • Disorders of glycosaminoglycan metabolism
    • Mucopolysaccharidosis I
      • Hurler syndrome (GDGDB) [IDUA]

Disorders by systems

• Genetic disorders of glycan degradation (by systems, signs and symptoms)
  • Diseases
    • Cardiovascular Diseases
      • Heart Diseases
        • Heart Valve Diseases
          • Hurler syndrome (GDGDB) [IDUA]
        • Hurler syndrome (GDGDB) [IDUA]
        • Myocardial Ischemia
          • Coronary Disease
            • Coronary Artery Disease
              • Hurler syndrome (GDGDB) [IDUA]
      • Vascular Diseases
        • Myocardial Ischemia
          • Coronary Disease
            • Coronary Artery Disease
              • Hurler syndrome (GDGDB) [IDUA]
    • Digestive System Diseases
      • Liver Diseases
        • Hepatomegaly
          • Hurler syndrome (GDGDB) [IDUA]
    • Eye Diseases
      • Corneal Diseases
        • Corneal Opacity
          • Hurler syndrome (GDGDB) [IDUA]
      • Ocular Hypertension
        • Glaucoma
          • Hurler syndrome (GDGDB) [IDUA]
      • Retinal Diseases
        • Retinal Degeneration
          • Hurler syndrome (GDGDB) [IDUA]
    • Hemic and Lymphatic Diseases
      • Lymphatic Diseases
        • Splenic Diseases
          • Hurler syndrome (GDGDB) [IDUA]
    • Musculoskeletal Diseases
      • Bone Diseases
        • Bone Diseases, Developmental
          • Dwarfism
            • Hurler syndrome (GDGDB) [IDUA]
          • Dysostoses
            • Hurler syndrome (GDGDB) [IDUA]
        • Spinal Diseases
          • Spinal Stenosis
            • Hurler syndrome (GDGDB) [IDUA]
      • Joint Diseases
        • Contracture
          • Hurler syndrome (GDGDB) [IDUA]
      • Musculoskeletal Abnormalities
        • Craniofacial Abnormalities
          • Macrocephaly
            • Hurler syndrome (GDGDB) [IDUA]
          • Maxillofacial Abnormalities
            • Hurler syndrome (GDGDB) [IDUA]
    • Nervous System Diseases
      • Central Nervous System Diseases
        • Brain Diseases
          • Intracranial Hypertension
            • Hydrocephalus
              • Hurler syndrome (GDGDB) [IDUA]
        • Spinal Cord Diseases
          • Spinal Cord Compression
            • Hurler syndrome (GDGDB) [IDUA]
      • Nervous System Malformations
        • Malformations of Cortical Development
          • Macrocephaly
            • Hurler syndrome (GDGDB) [IDUA]
      • Neuromuscular Diseases
        • Peripheral Nervous System Diseases
          • Mononeuropathies
            • Median Neuropathy
              • Carpal Tunnel Syndrome
                • Hurler syndrome (GDGDB) [IDUA]
          • Nerve Compression Syndromes
            • Carpal Tunnel Syndrome
              • Hurler syndrome (GDGDB) [IDUA]
      • Neurologic Manifestations
        • Neurobehavioral Manifestations
          • Communication Disorders
            • Learning Disorders
              • Hurler syndrome (GDGDB) [IDUA]
          • Intellectual Disability
            • Hurler syndrome (GDGDB) [IDUA]
        • Pain
          • Musculoskeletal Pain
            • Hurler syndrome (GDGDB) [IDUA]
        • Sensation Disorders
          • Hearing Disorders
            • Hearing Loss
              • Hurler syndrome (GDGDB) [IDUA]
          • Vision Disorders
            • Blindness
              • Hurler syndrome (GDGDB) [IDUA]
    • Otorhinolaryngologic Diseases
      • Ear Diseases
        • Otitis
          • Hurler syndrome (GDGDB) [IDUA]
        • Hearing Disorders
          • Hearing Loss
            • Hurler syndrome (GDGDB) [IDUA]
    • Pathological Conditions, Signs and Symptoms
      • Pathological Conditions, Anatomical
        • Hernia
          • Hernia, Abdominal
            • Hernia, Inguinal
              • Hurler syndrome (GDGDB) [IDUA]
            • Hernia, Ventral
              • Hernia, Umbilical
                • Hurler syndrome (GDGDB) [IDUA]
      • Signs and Symptoms
        • Mobility Limitation
          • Hurler syndrome (GDGDB) [IDUA]
        • Signs and Symptoms, Digestive
          • Constipation
            • Hurler syndrome (GDGDB) [IDUA]
          • Diarrhea
            • Hurler syndrome (GDGDB) [IDUA]
    • Respiratory Tract Diseases
      • Lung Diseases
        • Hurler syndrome (GDGDB) [IDUA]
      • Respiration Disorders
        • Apnea
          • Sleep Apnea Syndromes
            • Sleep Apnea, Obstructive
              • Hurler syndrome (GDGDB) [IDUA]
        • Hoarseness
          • Hurler syndrome (GDGDB) [IDUA]
        • Respiratory Insufficiency
          • Airway Obstruction
            • Hurler syndrome (GDGDB) [IDUA]
      • Respiratory Tract Infections
        • Hurler syndrome (GDGDB) [IDUA]
    • Skin and Connective Tissue Diseases
      • Connective Tissue Diseases
        • Mucinoses
          • Hurler syndrome (GDGDB) [IDUA]
    • Stomatognathic Diseases
      • Mouth Diseases
        • Tongue Diseases
          • Macroglossia
            • Hurler syndrome (GDGDB) [IDUA]
      • Stomatognathic System Abnormalities
        • Maxillofacial Abnormalities
          • Hurler syndrome (GDGDB) [IDUA]
  • Psychiatry and Psychology
    • Mental Disorders
      • Mental Disorders Diagnosed in Childhood
        • Developmental Disabilities
          • Hurler syndrome (GDGDB) [IDUA]
        • Intellectual Disability
          • Hurler syndrome (GDGDB) [IDUA]
        • Learning Disorders
          • Hurler syndrome (GDGDB) [IDUA]